PMID: 2507744Nov 1, 1989Paper

Long-term opiate exposure leads to reduction of the alpha i-1 subunit of GTP-binding proteins

Journal of Neurochemistry
B Attali, Z Vogel

Abstract

Desensitization or tolerance is a major consequence of long-term opiate exposure. The mechanism of opiate desensitization is only poorly understood. We report that exposure of rat spinal cord-dorsal root ganglion cocultured neurons to kappa-opiate agonist is accompanied by a 60-70% reduction in the level of the alpha i subunit of GTP-binding proteins. Using selective antibodies, which discriminate among the various alpha i subunit forms, it was found that the opiate treatment leads to a reduction in the amount of the alpha i-1 subunit. The levels of alpha s, alpha o, and beta subunits remain unchanged. This molecular event could underlie the development of tolerance and cross-tolerance to opiates.

References

Jan 9, 1989·Brain Research·E J NestlerJ F Tallman
Jul 12, 1988·Biochemistry·M A Lochrie, M I Simon

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Citations

Dec 17, 1991·Brain Research. Developmental Brain Research·A Tempel
Sep 1, 1996·Brain Research. Molecular Brain Research·N Matus-LeibovitchB Attali
Dec 1, 1991·Molecular and Cellular Endocrinology·C ReithmannK H Jakobs
Aug 1, 1991·Molecular and Cellular Endocrinology·C BouvierR Collu
Jun 1, 1991·Molecular and Cellular Endocrinology·C BouvierR Collu
Mar 20, 2002·Pharmacology, Biochemistry, and Behavior·Kumar V S Nemmani, Poduri Ramarao
Feb 26, 1998·Pharmacology, Biochemistry, and Behavior·D W RowenS P Welch
Aug 1, 1996·The Journal of Clinical Investigation·C SteinA H Hassan
Oct 6, 1997·Science·E J Nestler, G K Aghajanian
Apr 1, 1993·The Journal of Experimental Zoology·M D Rollag, G R Lynch
Jan 15, 1997·Biological Psychiatry·H ManjiT R Kosten

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