PMID: 8615355May 1, 1996Paper

Long-term oral vitamin E supplementation in cystic fibrosis patients: RRR-alpha-tocopherol compared with all-rac-alpha-tocopheryl acetate preparations

The American Journal of Clinical Nutrition
Brigitte M Winklhofer-RoobD H Shmerling

Abstract

To investigate the efficacy of three different vitamin E preparations for optimizing vitamin E status in cystic fibrosis (CF patients long-term, 29 patients (aged 0.7-29.8 y) were randomly assigned to receive 400 IU of either RRR-alpha-tocopherol (A: 268 mg, n = 10) or all rac-alpha-tocopheryl acetate as a fat-soluble (B: 400 mg, n = 10) or water-miscible preparation (C: 400 mg, n = 9) and were followed for 6 wk. In the whole study group, plasma alpha-tocopherol concentrations increased from baseline (10.5 +/- 4.6 micromol/L) to 3 wk (25.7 +/- 6.5 micromol/L; P < 0.001), but not further between 3 and 6 wk; concentrations at 3 and 6 wk did not differ from those of age-matched control subjects (23.6 +/- 3.9 micromol/L). There was no significant difference in the increase from baseline to 6 wk among preparations A (17.75 +/- 8.43 micromol/L), B (14.0 +/- 9.4 micromol/L), and C (15.5 +/- 7.1 micromol/L). Because of differences in body weight, the dose administered ranged from 5.5 to 47.4 IU x kg-1 x d-1; it correlated positively with the increase in plasma alpha-tocopherol concentrations (P < 0.001). There was no significant difference in the increase in plasma alpha-tocopherol concentrations between patients with CF-associated liv...Continue Reading

Citations

Jul 1, 1997·Journal of Pediatric Gastroenterology and Nutrition·B M Winklhofer-Roob
Oct 14, 2009·European Journal of Clinical Pharmacology·Tone Westergren, Betty Kalikstad
Oct 4, 2019·The Cochrane Database of Systematic Reviews·Oana CiofuJens Lykkesfeldt
May 15, 2001·Journal of the American College of Nutrition·L G WoodM L Garg
Jan 12, 2007·Digestive Diseases and Sciences·Konstantinos PapasRicky Mohon
Jun 12, 2008·Clinical Reviews in Allergy & Immunology·David P NicholsJames F Chmiel
Mar 19, 2013·Journal of Lipid Research·Maret G Traber
Mar 7, 2017·The Cochrane Database of Systematic Reviews·Peter O OkebukolaJoanne Barrett
Jul 28, 2004·The American Journal of Clinical Nutrition·Evelyn I BackHans K Biesalski
Nov 8, 2002·Journal of Chemotherapy·R C Choudhury, M B Jagdale
Mar 15, 2005·European Journal of Nutrition·Evelyn I BackHans K Biesalski
Feb 5, 2010·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Jennifer Doley
Aug 8, 2014·The Cochrane Database of Systematic Reviews·Oana Ciofu, Jens Lykkesfeldt
Jan 1, 1998·Nutritional Neuroscience·M J Fryer
Sep 7, 2020·The Cochrane Database of Systematic Reviews·Peter O OkebukolaJoanne Barrett
Aug 5, 2003·Journal of the American College of Nutrition·Lisa G WoodManohar L Garg
Sep 28, 2002·Journal of Pediatric Gastroenterology and Nutrition·Drucy BorowitzVirginia Stallings
Nov 14, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·S DevarajI Jialal
Feb 9, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Lisa G WoodManohar L Garg
Oct 6, 1998·Clinics in Chest Medicine·M W Konstan

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