Long-term outcome according to renal histological lesions in 118 patients with monoclonal gammopathies

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
J J MontsenyD Eladari

Abstract

The prognosis of monoclonal gammopathies with multiple myeloma and renal involvement is poor, and the indication for renal replacement therapy is controversial. Few studies address the value of renal histology for determining prognosis according to initial pathology findings. We studied the course of 118 patients with multiple myeloma according to renal biopsy lesions. The monoclonal component was identified and quantified in serum and urine. Tumor cell mass was classified as stage 1, 2 or 3, according to Durie and Salmon. End-points were death, or survival on dialysis, or serum creatinine level at last examination. Renal biopsy showed myeloma kidney in 48 cases (41%), AL-amyloidosis in 35 (30%), light chain deposit disease in 22 (19%), chronic tubulointerstitial nephritis in 12 (10%) and cryoglobulinaemic kidney with multiple myeloma in 1. Maintenance haemodialysis was required in 46 patients (39%), earlier (P<0.0001) in myeloma kidney (mean: 3 months after diagnosis) than in AL-amyloidosis (mean: 15 months) and light chain deposit disease (mean: 18 months). Median survival was 12 months in myeloma kidney, 24 months in AL-amyloidosis and 48 months in light chain deposit disease. Dialysis increased survival in light chain depos...Continue Reading

Citations

Dec 15, 2010·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Sanjeev BawejaLawrence P McMahon
Jan 6, 2010·Medical Oncology·Metin Isik
Jun 6, 2002·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·A CorsoM Lazzarino
Aug 26, 2006·Nature Clinical Practice. Nephrology·François Madore
Sep 30, 2009·Nature Reviews. Nephrology·Colin A HutchisonPaul Cockwell
Nov 3, 2011·Nature Reviews. Nephrology·Colin A HutchisonUNKNOWN International Kidney and Monoclonal Gammopathy Research Group
Feb 22, 2012·Nature Reviews. Nephrology·Colin A HutchisonUNKNOWN International Kidney and Monoclonal Gammopathy Research Group
Sep 21, 2001·British Journal of Haematology·A BadrosG Tricot
Jan 12, 2002·Kidney International·Morie A GertzAngela Dispenzieri
May 1, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Morie A GertzThomas E Witzig
Dec 29, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Dimitrios J TsakirisKitty J Jager
Oct 21, 2006·Current Opinion in Nephrology and Hypertension·Tahmina Rahman, Lorraine Harper
Aug 9, 2006·Seminars in Dialysis·Jeffrey G Penfield
Mar 21, 2012·Seminars in Dialysis·Amber P Sanchez, David M Ward
Oct 12, 2010·Internal Medicine·Yuko IwabuchiKosaku Nitta
Jul 24, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Richard FishColin A Hutchison
Aug 11, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Albert Q Lam, Benjamin D Humphreys
Apr 3, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Colin A HutchisonPaul Cockwell
Jul 22, 2014·Case Reports in Nephrology·Bhanu K PatibandlaRobert M Black
Mar 13, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Antoine SicardGuy Touchard
Oct 22, 2014·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Partha PalKaushik Kumar Das
Mar 26, 2011·Clinical and Experimental Nephrology·Shiho HanawaEiji Kusano
Aug 23, 2000·Leukemia & Lymphoma·A ViertelH Geiger
Jan 26, 2012·Expert Review of Hematology·Mahmoud R GaballaPaul G Richardson
Oct 24, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Colin A HutchisonPaul Cockwell
Oct 16, 2012·Revista española de geriatría y gerontología·Manuel HerasMaría José Fernández-Reyes
Jun 4, 2013·Néphrologie & thérapeutique·Saloua Ait El Haj, Alexandre Hertig
Aug 21, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Laure EcotièreFrank Bridoux
Mar 16, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Samih H NasrNelson Leung
May 3, 2011·Néphrologie & thérapeutique·Sophie CaillardBruno Moulin
Apr 19, 2011·Néphrologie & thérapeutique·Estelle DesportArnaud Jaccard
May 21, 2010·La Revue de médecine interne·N Jourde-ChicheL Daniel
May 20, 2008·Primary Care·Asha RajashekarSusan Crowley
Jan 6, 2016·Clinical Journal of the American Society of Nephrology : CJASN·Alexandre DecourtNoemie Jourde-Chiche
Dec 5, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Claudio PozziFrancesco Locatelli
Mar 22, 2016·Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia·Tayebeh SoleymanianGholamreza Hamid
Oct 6, 2005·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Tarek M El-AchkarJesus Dominguez
Aug 4, 2007·Acta Clinica Belgica·N Lameire
Oct 6, 2006·American Journal of Hematology·Mohammad Reza Ardalan, Mohammadali Mohajel Shoja
Jul 22, 2010·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Julia K ZimmerUyen Huynh-Do
Oct 20, 2010·Hemodialysis International·Diptesh GuptaMadhukar Misra

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