Long-term outcome and prognostic factors of intramedullary spinal hemangioblastomas

Neurosurgical Review
Saravanan SadashivamSuresh Nair

Abstract

Spinal hemangioblastomas constitute 1.6-5.8% of all spinal cord tumors. Microsurgical excision of these tumors is challenging. The purpose of this study is to analyze the neurological improvement and long-term functional outcome of spinal hemangioblastomas. This retrospective study included 15 patients who underwent surgery for intramedullary spinal hemangioblastoma at the Department of Neurosurgery of Sri Chitra Tirunal Institute for Medical Sciences and Technology from January 2001 to June 2014. Eight patients (53%) were diagnosed to have von Hippel-Lindau (vHL) disease. Eight (53%) of them were females, and seven were males (47%). Mean age was 33.8 years (16-55 years). Duration of illness ranged from 2 weeks to 4 years, and average duration was 10.5 months. Most common symptom was motor weakness followed by sensory disturbances, pain, and bladder incontinence. Six (85.7%) sporadic spinal hemangioblastomas were in McCormick grade I; whereas, 7 (87.5%) of vHL spinal hemangioblastomas were in grade II or above. In the immediate postoperative period, three patients noticed improvement in their motor weakness. Six patients (40%) experienced deterioration of preoperative neurological status in the immediate postoperative period. T...Continue Reading

References

Jun 1, 1976·Archives of Neurology·T R BrowneG H Roberson
Apr 1, 1990·Journal of Neurosurgery·P C McCormickB M Stein
Jun 3, 1999·Acta neurochirurgica·L Cristante, H D Herrmann
Dec 11, 1999·Acta neurochirurgica·M NiemeläJ Jääskeläinen
Feb 5, 2000·AJR. American Journal of Roentgenology·K B BakerT L Siegal
Nov 22, 2000·Acta neurochirurgica·T A PietiläM Brock
Jul 24, 2002·Journal of Neurosurgery·James T Rutka
Jan 28, 2003·Journal of Neurosurgery·Russell R LonserEdward H Oldfield
Apr 1, 1964·The American Journal of Medicine·K L MELMON, S W ROSEN
Sep 19, 2008·JAMA : the Journal of the American Medical Association·John A ButmanRussell R Lonser
Sep 24, 2008·Neurosurgical Review·Jens RachingerChristian Strauss
Nov 26, 2008·Spinal Cord·H KannoUNKNOWN Clinical VHL Research Group in Japan
Nov 26, 2009·Neurosurgery·Christopher E MandigoPaul C McCormick
Mar 3, 2010·Journal of Neurosurgery. Spine·Gautam U MehtaRussell R Lonser
Jan 11, 2011·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·M M BeitnerK J Drummond
May 2, 2013·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Dandan JiaHong Jiang

❮ Previous
Next ❯

Citations

Feb 5, 2021·World Neurosurgery·Mustafa Umut EtliSait Naderi
Apr 21, 2021·British Journal of Neurosurgery·Nicolò MarchesiniGiampietro Pinna

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.