PMID: 16613659Apr 15, 2006Paper

Long-term outcome for mammographically detected ductal carcinoma in situ managed with breast conservation treatment: prognostic significance of reexcision

The Cancer Journal
Neha VapiwalaLawrence J Solin

Abstract

The importance of negative final resection margins for optimal local control has been established for women with ductal carcinoma in situ (intraductal carcinoma) undergoing breast conservation treatment. This study evaluated long-term outcome after breast conservation treatment and whether reexcision or the presence of residual tumor in the reexcision specimen predicted for local recurrence in patients with ductal carcinoma in situ with negative margins. The study cohort consisted of 192 women with ductal carcinoma in situ treated with breast conservation treatment at the University of Pennsylvania from 1978 to 2000. Analysis was performed for unilateral, mammographically detected, intraductal breast carcinomas. Study endpoints of interest included rates of local recurrence, overall survival, and cause-specific survival. The median follow-up was 6.2 years (mean, 7 years; range, 0.1-21.4 years). The 10-year overall survival and 10-year cause-specific survival rates were 87% and 99%, respectively. There were 11 local failures (6%) in the treated breast, with a 10-year actuarial local failure rate of 10% and a median time to local failure of 7.4 years (mean, 6.6 years; range, 1.6-10.2 years). Among the subset of 124 patients with ...Continue Reading

References

Oct 1, 1985·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A RechtJ R Harris
Mar 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·L J SolinM McNeese
Jun 1, 1996·Cancer·M J SilversteinD N Poller
Jul 15, 1997·International Journal of Radiation Oncology, Biology, Physics·B FowbleH Kessler
Oct 23, 1997·International Journal of Radiation Oncology, Biology, Physics·J M MillsL J Solin
Feb 20, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B FisherM Kavanah
Nov 10, 2000·International Journal of Radiation Oncology, Biology, Physics·E E HarrisL J Solin
Apr 17, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·N BijkerM J van de Vijver
May 18, 2001·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·G Noël, J J Mazeron
Feb 21, 2004·CA: a Cancer Journal for Clinicians·Ahmedin JemalUNKNOWN American Cancer Society
Mar 18, 2004·Journal of the National Cancer Institute·Nancy N BaxterTodd M Tuttle
Apr 9, 2004·The New England Journal of Medicine·Harold J BursteinCarolyn M Kaelin

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Citations

Apr 15, 2006·The Cancer Journal·Barbara A Ward, Linda Latrenta
Nov 8, 2007·Annals of Surgical Oncology·Philip MeijnenEmiel J Th Rutgers
Oct 20, 2010·Journal of the National Cancer Institute. Monographs·Tatyana ShamliyanRobert L Kane
Jan 19, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lawrence J SolinMitchell D Schnall
May 25, 2010·Korean journal of urology·Tae-Kon Hwang
Jul 1, 2020·BioMed Research International·Yufei LiuQing Wang

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