Long-term outcome in children with neonatal seizures: A tertiary center experience in cohort of 168 patients

Epilepsy & Behavior : E&B
Biljana Vucetic TadicVladislav Vukomanovic

Abstract

The purpose of this study was to evaluate long-term outcome and assess predictors of prognosis in children with neonatal seizures (NS). This retrospective study includes children with NS treated at our Institute from January the 1st 2005 until December the 31st 2015. The data were collected from medical charts and the electroencephalogram (EEG) database at the Institute. The predictive value was evaluated for following parameters: (1) characteristics of the patients, such as gender, gestational age, birth body weight, Apgar score, artificial ventilation; (2) etiology; (3) characteristics of seizures such as type, time of onset, resistance to treatment; and (4) EEG background activity and paroxysmal discharges. The outcome of NS was assessed at the end of the follow-up period and was categorized as one of the following: (1) lethal outcome, (2) neurological abnormalities, (3) intellectual disability, and (4) epilepsy. Univariate and multivariate logistic regression analyses were used to assess predictors of NS outcome. The study included 168 children with NS (of which 109 are males, and 59 are females), mean aged 5.6 (SD 3.5) years at the end of the follow-up (with a range of 1 to 12 years). There was normal neurological developm...Continue Reading

Citations

Jun 20, 2021·Brain : a Journal of Neurology·Dongfang ZouJian Guo

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