PMID: 7525913Nov 1, 1994Paper

Long-term outcome in children with opsoclonus-myoclonus and ataxia and coincident neuroblastoma

The Journal of Pediatrics
P S KohS L Cohn

Abstract

We reviewed the neurologic and developmental courses in 10 children with opsoclonus-myoclonus ("dancing eyes syndrome") and neuroblastoma. All patients are alive without evidence of neoplastic disease after 8+ to 111+ months of follow-up. All had localized disease and 50% had extraabdominal tumors. Neuroblastomas of nine children had favorable Shimada histologic characteristics, and all tumors had single copies of the N-myc oncogene. After neuroblastoma resection, all patients had persistent opsoclonus-myoclonus or ataxia that responded to therapy with adrenocorticotropic hormone. Nine children had relapses of neurologic symptoms. Three years after resection, six of seven patients with sufficient follow-up were free of symptoms and had discontinued therapy. However, nine children had chronic neurologic deficits, including cognitive and motor delays, language deficits, and behavioral abnormalities. All six patients in educational programs required special assistance. Five children required physical, occupational, or speech therapy. Long-term developmental and cognitive problems should be anticipated in patients with neuroblastoma who have opsoclonus-myoclonus or ataxia or both, and early intervention should be instituted to try ...Continue Reading

References

Jan 1, 1979·Archives of Neurology·F A ZiterP A Cancilla
Apr 1, 1990·Journal of Child Neurology·W G Mitchell, S R Snodgrass
Jan 1, 1989·Journal of Pediatric Surgery·R L TelanderR V Groover
Jun 1, 1987·Cancer·A E EvansH W Hann
Jan 1, 1985·Clinical Pediatrics·R P WarrierU Raju
Oct 31, 1985·The New England Journal of Medicine·R C SeegerD Hammond
Oct 1, 1973·Journal of Pediatric Surgery·R C SenelickD G Johnson
Apr 1, 1972·Journal of Pediatric Surgery·R M FillerG F Vawter
Dec 1, 1969·The Journal of Pediatrics·P F BrayG G Myers
Jan 1, 1967·Transactions of the American Neurological Association·A T Ross, W Zeman
Aug 29, 1968·The New England Journal of Medicine·G E Solomon, A M Chutorian
Aug 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M SchwabJ M Bishop

❮ Previous
Next ❯

Citations

Dec 17, 2010·Current Neurology and Neuroscience Reports·Elizabeth M Wells, Josep Dalmau
Jan 11, 2003·Current Treatment Options in Neurology·Myrna R. Rosenfeld, Josep Dalmau
May 1, 1995·The Journal of Pediatrics·W T BascoK R Holden
Mar 25, 1998·Journal of the Neurological Sciences·E J Dropcho
Feb 22, 2001·Pediatric Neurology·V W YiuP Ferreira
Feb 11, 2000·Pediatric Neurology·A V WhiteI R Toogood
Oct 7, 2008·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Kyoichi Nomura
Nov 8, 2006·European Journal of Pediatrics·Andrea KleinEugen Boltshauser
Jan 21, 2016·Brain & Development·Michael R Pranzatelli, Elizabeth D Tate
Jan 30, 2010·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Pauline KrugMarc Tardieu
May 9, 2009·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·K Ki PangMichael G Pike
Jul 13, 2007·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·B WilkenF Hanefeld
Jun 5, 2007·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·J ChemliA Harbi
Sep 29, 2011·Developmental Medicine and Child Neurology·Hilla Ben-PaziRuth S Shalev
Aug 13, 2009·Pediatric Blood & Cancer·Coriene E Catsman-BerrevoetsMarry M van den Heuvel-Eibrink
Dec 28, 2004·Parkinsonism & Related Disorders·Fernando Alarcón, Santiago Giménez-Roldán
Apr 17, 2004·Pediatric Neurology·Burak TatliSema Anak
Apr 1, 1995·The Journal of Pediatrics·M C Chamberlain
Jul 1, 2008·Magnetic Resonance Imaging Clinics of North America·Marilyn J Siegel, Alok Jaju
Apr 21, 2016·Expert Review of Neurotherapeutics·Franz Blaes, Backialakshmi Dharmalingam
Jan 5, 2002·Neurologic Clinics·Edward J Dropcho
Sep 1, 1996·Pediatric Hematology and Oncology·J Blatt
Dec 3, 2004·Journal of Pediatric Oncology Nursing : Official Journal of the Association of Pediatric Oncology Nurses·Elizabeth D TateSteven J Verhulst
Jun 26, 2003·Journal of Child Neurology·Monique M Ryan, Elizabeth C Engle
Oct 3, 2003·Hospital Medicine·Imogen StoreySarah Denniston
Dec 5, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Michael R PranzatelliBibhuti Mishra
Aug 11, 2006·Pediatric Blood & Cancer·Michael J Burke, Susan L Cohn
Jun 16, 2005·Journal of Pediatric Hematology/oncology·Linsey S Mutch, Donna L Johnston
Sep 28, 2010·Current Opinion in Pediatrics·Mark P Gorman
May 30, 2003·The Oncologist·Joanna L WeinsteinSusan L Cohn
Jul 23, 2020·Developmental Medicine and Child Neurology·Andrew SheridanMark P Gorman
Jul 21, 1998·Annals of the New York Academy of Sciences·E J Dropcho

❮ Previous
Next ❯

Related Concepts

Related Feeds

Ataxias

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on different types of ataxias here.

Ataxias (MDS)

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

Ataxia

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.