Long-term outcome of acute myocarditis is independent of cardiac enzyme release

International Journal of Cardiology
Peter AmmannOsmund Bertel

Abstract

There are few data concerning prognostic markers of acute myocarditis. The purpose of this study was to assess the prognostic value of initial measurements of creatine kinase (CK), cardiac troponin I (cTnI) and myoglobin as regards late recovery of the left ventricular ejection fraction on follow-up. A total of 22 patients (53+/-15 years old, 11 female) with acute myocarditis were followed up in a prospective observational study. Of these, 11 (50%) showed a history of acute infection prior to hospitalisation and seven (32%) had pericardial effusion. The median ejection fraction during the acute phase was 47+/-17%; after a mean follow-up of 119+/-163 days it improved to 60+/-9% (P<0.001). Considering maximal CK-rise values of 641+/-961 U/l (P=0.38), cTnI-rise values of 3.7+/-8.6 microg/l (P=0.16) and myoglobin values of 7.4+/-12 nmol/l (P=0.69), there was no correlation between initial cardiac enzyme levels and the initial and late left ventricular ejection fraction. After acute myocarditis, there is late recovery of left ventricular ejection fraction, which is independent of the initial myocardial damage measured by cardiac enzyme release.

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Citations

Dec 22, 2009·Herz·Michel NoutsiasBernhard Maisch
Jun 1, 2011·The American Journal of Cardiology·Peter OngHeiko Mahrholdt
May 27, 2014·The American Journal of Emergency Medicine·Carlos Ramos-MatosMaya Guglin
Jan 16, 2016·Journal of Cardiac Failure·Nisha A GilotraStuart D Russell
Feb 26, 2016·International Journal of Cardiology·Yifan FanXinchun Yang
May 5, 2011·Echocardiography·Marina LeitmanZvi Vered
Nov 23, 2015·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Michael JeserichChristoph Bode
Sep 20, 2005·Journal of the American College of Cardiology·Douglas L Mann
Apr 25, 2009·Journal of the American College of Cardiology·Matthias G FriedrichUNKNOWN International Consensus Group on Cardiovascular Magnetic Resonance in Myocarditis
Sep 28, 2013·Archives of Cardiovascular Diseases·François RoubilleJean-Claude Tardif
Mar 25, 2004·Expert Review of Cardiovascular Therapy·Michel NoutsiasUwe Kühl
Jan 14, 2020·Journal of Magnetic Resonance Imaging : JMRI·Łukasz A MałekBożena Werner
Feb 2, 2020·Journal of Cardiovascular Translational Research·Jan KottwitzBettina Heidecker
Jul 16, 2005·Annales Françaises D'anesthèsie Et De Rèanimation·C BerroëtaI Philip

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