Abstract
It has previously been shown that bone mineral density (BMD) during the first year after orthotopic liver transplantation (OLT) in children with osteodystrophy increases remarkably and according to height. The effect of posttransplant factors possibly influencing bone mass in the long-term after a successful OLT in children is unknown. Eighteen patients (9 male), median age 13.3 (range 4.7-23.7) years, median time after OLT 8.3 (1.1-17.3) years were enrolled. Indications for OLT were biliary atresia (8), Alagille (3), hepatoblastoma (2), NonA-NonG acute liver failure (2), intrahepatic cholestasis, cryptogenic cirrhosis, and cholesteryl-ester disease (1 each). At OLT, all were prepubertal and 12 were severely cholestatic. We recorded anthropometric data, immunosuppression, dual-energy x-ray absorptiometry (DXA), biochemical markers of bone metabolism, and liver function. Six children were on steroid therapy, eight were on cyclosporine, nine on tacrolimus. Median L1 to L4 spinal BMD was 0.720 (range 0.524-1.127) g/cm3, Z score -0.70 (-2.2- +2.1), height Z score -0.31 (-1.83- +1.96). Median bone mineral apparent density was 0.112 (0.084-0.142) (normal value 0.10-0.14) g/cm3. Median alanine aminotransferase level was 22 (range 11-7...Continue Reading
References
Jun 1, 1979·The Journal of Pediatrics·S W KoohD Fraser
Jan 1, 1976·Acta paediatrica Scandinavica·J F Glasgow, P S Thomas
Feb 1, 1992·Pediatric Research·E A ArgaoR C Tsang
Feb 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D R CarterR Marcus
Nov 1, 1988·Endocrinology·C MovsowitzS Thomas
Aug 1, 1974·Archives of Disease in Childhood·A KobayashiY Obe
Dec 1, 1981·Journal of Steroid Biochemistry·B E NordinR G Crilly
May 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J C RuizM Garabedian
Apr 1, 1995·European Journal of Endocrinology·H BellE Haug
Nov 1, 1994·The American Journal of Medicine·E MeysP D Delmas
Sep 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E A ArgaoJ E Heubi
Sep 11, 1993·Lancet·G Fry, V Kenny
Sep 11, 1993·Lancet·E SchönaüK Klein
Mar 1, 1994·The Journal of Pediatrics·P Codoner-FranchF Alvarez
Oct 1, 1996·Journal of Gastroenterology·K TsuneokaT Nakano
Feb 1, 1997·The American Journal of Clinical Nutrition·R I HoltG Mieli-Vergani
Dec 1, 1995·Scandinavian Journal of Gastroenterology·M AbdelhadiJ Nordenström
Sep 1, 1997·Journal of Pediatric Gastroenterology and Nutrition·J E HeubiB L Specker
Aug 1, 1998·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·E Schönau
Sep 2, 1998·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·H L ReevesC P Day
Sep 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F J Gallego-RojoD Rodrigo-Moreno
Mar 23, 1999·Archives of Disease in Childhood·S M HusainW D Fraser
Jul 29, 1999·Journal of Hepatology·S OrmarsdóttirL Lööf
Aug 3, 1999·Calcified Tissue International·M BjørgaasH J Johnsen
Aug 4, 1999·The Journal of Pediatrics·M B LeonardH I Feldman
Sep 22, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S MoraV Gilsanz
Nov 5, 1999·The Journal of Pediatrics·S M BartoshP F Whitington
Sep 12, 2000·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·N CrabtreeJ Reev
Nov 9, 2000·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S M HamburgE B Haagsma
Dec 22, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S Rouillard, N E Lane
May 23, 2001·Archives of Disease in Childhood·M SoodM Z Mughal
Jun 27, 2002·Transplantation·Lorenzo D'AntigaAnil Dhawan
Mar 23, 2004·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·G Manjón LlorenteA Baldellou Vázquez
Citations
Apr 14, 2007·Pediatric Radiology·Larry A BinkovitzMaria J Henwood
Jul 3, 2008·Pediatric Radiology·Larry A BinkovitzPaul Sparke
May 22, 2007·Current Gastroenterology Reports·William R Treem
Nov 10, 2005·Transplantation·Pekka Arikoski, Christer Holmberg
Mar 25, 2014·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Maria Luisa BianchiLeanne Ward
Dec 14, 2011·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Edyta KryskiewiczRoman S Lorenc
Apr 30, 2008·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Nick BishopMaria Luisa Bianchi
Jun 5, 2007·Seminars in Nuclear Medicine·Larry A BinkovitzPaul Sparke
Nov 2, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·H ValtaO Mäkitie
Jul 10, 2013·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Deirdre A KellyUNKNOWN American Society of Transplantation
Aug 22, 2013·Pediatric Transplantation·Maria LegardaPatrick McKiernan
Jun 27, 2006·Transplantation Proceedings·K KhanH Sharp
Sep 27, 2015·JPEN. Journal of Parenteral and Enteral Nutrition·Diana MagerJason Yap
Dec 30, 2017·Journal of Pediatric Gastroenterology and Nutrition·Looi C EeGeoffrey J Cleghorn
Nov 9, 2011·Journal of Pediatric Gastroenterology and Nutrition·Wolfgang HöglerDeirdre Kelly
Apr 25, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Estella M Alonso
Jun 2, 2011·Journal of Pediatric Gastroenterology and Nutrition·Scott NightingaleVicky L Ng
Mar 30, 2018·Bone·Melissa S PutmanDebra Boyer
Apr 10, 2021·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Masaki HondaTaizo Hibi