Long-term outcome of chronic obstructive pulmonary disease patients with acute respiratory failure following intensive care unit discharge in Turkey

The Clinical Respiratory Journal
Serpil OcalLutfi Coplu

Abstract

Chronic obstructive pulmonary disease (COPD) remains a globally significant cause of mortality, although COPD mortality varies from country to country, and across different regions within each country. The primary objective of this study was to determine the mortality rates of COPD patients who present with acute respiratory failure (ARF) to a tertiary care referral center in different stages of their follow-up (ICU, in-hospital and after discharge). The secondary objective was to determine factors associated with mortality in this group of patients. Medical records of consecutive COPD patients over a 10-year period were reviewed.The study included 147 patients. Of these, 72 were treated initially with noninvasive positive pressure ventilation (NIPPV), and 12 of these required intubation after NIPPV failed. Therefore, 86 patients were intubated for invasive mechanical ventilation (IMV), while NIPPV was succesful in 60 patients. Survival time was independently associated with advanced age, high APACHE II score, co-morbidity and the need for IMV. The cumulative mortality was 27% in the medical ICU and 31% in hospital following ICU discharge. The mortality rate at 1, 2 and 5 years was 54%, 66% and 84%, respectively. COPD patients ...Continue Reading

References

Mar 17, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·L P FriedUNKNOWN Cardiovascular Health Study Collaborative Research Group
May 8, 2004·Experimental Gerontology·Karen Suárez KrabbeHelle Bruunsgaard
Jul 20, 2006·Critical Care Medicine·Ricardo Rivera-FernándezUNKNOWN Project for the Epidemiological Analysis of Critical Care Patients (PAEEC) Group
May 18, 2007·American Journal of Respiratory and Critical Care Medicine·Klaus F RabeUNKNOWN Global Initiative for Chronic Obstructive Lung Disease
Sep 4, 2007·Lancet·A Sonia BuistUNKNOWN BOLD Collaborative Research Group
Jan 2, 2008·The European Respiratory Journal·L M FabbriK F Rabe
May 6, 2008·Proceedings of the American Thoracic Society·Jeremy A FalkPhilip Diaz
Nov 18, 2008·European Journal of Internal Medicine·Hakan GunenErkan Pehlivan
May 4, 2011·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Mariângela Pimentel PincelliIsrael Silva Maia
Oct 22, 2011·American Journal of Respiratory and Critical Care Medicine·Divay ChandraFernando Holguín
Jan 1, 2011·Multidisciplinary Respiratory Medicine·Serap A BarışAhmet Ilgazlı
Dec 28, 2012·International Journal of Chronic Obstructive Pulmonary Disease·Abdulsalam M AlaithanAbdul Salam

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Citations

Jan 11, 2011·Medicina intensiva·E García VicenteJ C Salgado Campo
Apr 28, 2016·The Clinical Respiratory Journal·Cristiana CruzAntonio Esquinas

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