Long-term outcome of cryopreserved allograft for aortic valve replacement

The Journal of Thoracic and Cardiovascular Surgery
Francesco NappiChristophe Acar

Abstract

The most efficient surgical approach to severe aortic valve disease in the young adult is still debated: cryopreserved aortic allograft offers excellent hemodynamic and avoid anticoagulation, but long-term durability is influenced by structural valve deterioration (SVD). This study aimed to describe long-term results of aortic allografts and to identify factors influencing long-term durability. From January 1993 to August 2010, 210 patients underwent aortic allograft replacement via the free-hand subcoronary implantation technique (N = 55) or root replacement with coronary reimplantation (N = 155). Clinic and echocardiographic follow-up was updated to April 2016. Overall mortality and cardiac mortality occurred in 80 (38.1%) and 64 (30.5%) patients, respectively. Reoperation was required in 69 cases (32.8%), whereas SVD required reoperation in 57 cases (27.1%). No early endocarditis occurred, whereas late endocarditis occurred in 4 patients. The free-hand technique seems to be associated with improved left ventricular remodeling compared with the root-replacement technique, and smaller allograft size represents a predictor of reoperation independently on the surgical technique used. In the overall population, there were 44 wome...Continue Reading

Citations

May 19, 2019·Interactive Cardiovascular and Thoracic Surgery·Stoyan KondovMartin Czerny
Aug 15, 2020·Expert Review of Cardiovascular Therapy·Nikolaos PoulisMaximilian Y Emmert
Sep 11, 2020·Nature Reviews. Cardiology·Emanuela S FiorettaMaximilian Y Emmert
Sep 25, 2020·Tissue Engineering. Part B, Reviews·Alicia Fernández-Colino, Stefan Jockenhoevel
Nov 11, 2020·Journal of Cardiac Surgery·Olga N KislitsinaS Christopher Malaisrie
Oct 23, 2020·Clinical Medicine Insights. Cardiology·Francesco NappiIrina Timofeeva
Sep 29, 2020·The Annals of Thoracic Surgery·James C WittenGösta B Pettersson
Jan 12, 2019·The Journal of Thoracic and Cardiovascular Surgery·Juan A Crestanello
Jan 12, 2019·The Journal of Thoracic and Cardiovascular Surgery·Manuel J Antunes
Jun 18, 2021·BioMed Research International·Adelaide IervolinoFrancesco Nappi
Jul 25, 2021·Journal of Clinical Medicine·Ilaria GiambuzziMarco Zanobini
Feb 5, 2021·The Annals of Thoracic Surgery·Francesco Nappi, Christophe Acar

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