Long-term outcome of idiopathic steroid-resistant nephrotic syndrome in children

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Aya InabaMasataka Honda

Abstract

Several recent studies have shown improved short-term outcome of steroid-resistant nephrotic syndrome (SRNS) in children; however, only a few studies have evaluated the long-term outcome. The aims of our study were to obtain detailed data and analyze the long-term outcome of children with SRNS. Sixty-nine children with idiopathic SRNS were enrolled and divided into two groups based on initial histopathological patterns: focal segmental glomerulosclerosis (FSGS) and minimal change (MC)/diffuse mesangial proliferation (DMP). The effects of initial treatment with the immunosuppressant of choice (cyclosporine or cyclophosphamide) on renal survival, remission, and incidence of complications were analyzed in both groups (4 subgroups). The renal survival rate was significantly different among the four different subgroups based on different combinations of initial histopathological pattern (FSGS vs. MC/DMP) and initial immunosuppressant used for treating SRNS (cyclosporine vs. cyclophosphamide) (P = 0.013), with renal survival in the FSGS (cyclophosphamide) subgroup being especially low (54.6 %). Disease- and/or treatment-associated complications were relatively low; however, hypertension at last examination was observed in a considera...Continue Reading

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Citations

Oct 24, 2015·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Shuichiro Fujinaga, Yasuko Urushihara
Dec 3, 2015·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Aya InabaTetsuji Kaneko
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Apr 18, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Anna EichingerBärbel Lange-Sperandio
Nov 22, 2019·The Cochrane Database of Systematic Reviews·Isaac D LiuElisabeth M Hodson
Feb 23, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jiwon M LeeJun Oh
Mar 24, 2018·World Journal of Pediatrics : WJP·Luisa SantangeloMario Giordano
Aug 6, 2019·Frontiers in Pediatrics·Ibrahim F ShatatRobert P Woroniecki

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