Long-term outcome of induction chemoradiotherapy with docetaxel and cisplatin followed by surgery for non-small-cell lung cancer with mediastinal lymph node metastasis.

Interactive Cardiovascular and Thoracic Surgery
Shinichi ToyookaHiroshi Date

Abstract

The purpose of this study was to show the long-term outcome of induction chemoradiotherapy, using docetaxel and cisplatin with concurrent radiotherapy followed by surgery for non-small-cell lung cancer (NSCLC) with mediastinal nodal metastasis. Between January 2000 and July 2006, 22 consecutive NSCLC patients with pathologically proven mediastinal nodal metastasis were treated with tri-modality therapy. The regimen consisted of docetaxel and cisplatin plus concurrent radiation at a dose of 40-46 Gy. The induction therapy was followed by surgery 4-6 weeks later. The pulmonary resections were composed of a lobectomy in 19 patients, including 3 with a sleeve lobectomy, a bilobectomy in 2 patients and a left pneumonectomy in 1 patient. With a median follow-up duration of 8.7 years, the 3-year and 7-year overall survival (OS) rates for the entire population were 72.7 and 63.6%, respectively. Our results suggest that tri-modality therapy is promising for NSCLC patients with mediastinal nodal metastasis.

References

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Mar 22, 2007·Journal of the National Cancer Institute·Jan P van MeerbeeckUNKNOWN European Organisation for Research and Treatment of Cancer-Lung Cancer Group
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Citations

Jun 5, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Shinichi ToyookaShinichiro Miyoshi
Mar 4, 2014·Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·Hiroyuki TaoShinichiro Miyoshi
Jun 11, 2015·Respirology : Official Journal of the Asian Pacific Society of Respirology·Biniam KidaneKazuhiro Yasufuku
Sep 13, 2014·Surgery Today·Shinichi ToyookaShinichiro Miyoshi
Sep 23, 2016·Japanese Journal of Clinical Oncology·Kazuhiko Shien, Shinichi Toyooka
Jul 5, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Shinichi ToyookaShinichiro Miyoshi
Apr 24, 2018·Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·Hiroki SatoShinichi Toyooka
Oct 18, 2020·The Annals of Thoracic Surgery·Junichi SohShinichi Toyooka

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