Long-term outcome of infliximab combined with surgery for perianal fistulizing Crohn's disease

World Journal of Gastroenterology : WJG
Bo-lin YangWan-Jin Shao

Abstract

To evaluate the efficacy and long-term outcome of infliximab combined with surgery to treat perianal fistulizing Crohn's disease (CD). The work was performed as a prospective study. All patients received infliximab combined with surgery to treat perianal fistulizing CD, which was followed by an immunosuppressive agent as maintenance therapy. A total of 28 patients with perianal fistulizing CD were included. At week 30, 89.3% (25/28) of the patients were clinically cured with an average healing time of 31.4 d. The CD activity index decreased to 70.07±77.54 from 205.47±111.13 (P<0.01) after infliximab treatment. The perianal CD activity index was decreased to 0.93±2.08 from 8.54±4.89 (P<0.01). C-reactive protein, erythrocyte sedimentation rate, platelets, and neutrophils all decreased significantly compared with the pretreatment levels (P<0.01). Magnetic resonance imaging results for 16 patients after therapy showed that one patient had a persistent presacral-rectal fistula and another still had a cavity without clinical symptoms at follow-up. After a median follow-up of 26.4 mo (range: 14-41 mo), 96.4% (27/28) of the patients had a clinical cure. Infliximab combined with surgery is effective and safe in the treatment of perianal...Continue Reading

References

May 6, 1999·The New England Journal of Medicine·D H PresentS J van Deventer
Nov 20, 2001·Annals of Internal Medicine·D A SchwartzW J Sandborn
Jun 20, 2002·Diseases of the Colon and Rectum·Lisa S PoritzWalter A Koltun
Feb 27, 2004·The New England Journal of Medicine·Bruce E SandsSander J van Deventer
May 12, 2005·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·A OrlandoUNKNOWN Italian Multicentric Study Group on Infliximab
Feb 17, 2006·Gut·R CaprilliUNKNOWN European Crohn's and Colitis Organisation
Apr 19, 2006·Gastroenterology·Marc LémannUNKNOWN Groupe d'Etude Therapeutique des Affections Inflammatoires du Tube Digestif (GETAID)
May 9, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Gary R LichtensteinWilliam J Sandborn
Oct 17, 2006·Diseases of the Colon and Rectum·Syed A HyderBruce D George
Aug 29, 2007·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·S Ardizzone, G Bianchi Porro
Jun 1, 1934·Annals of Surgery·A D Bissell
Sep 28, 2007·Diseases of the Colon and Rectum·Wolfgang B GaertnerMichael P Spencer
May 13, 2009·The British Journal of Surgery·P J van KoperenJ F M Slors
Jun 21, 2011·Pharmacoepidemiology and Drug Safety·John Paul LeombrunoTom Einarson
Sep 23, 2011·Hepato-gastroenterology·Masayuki HotokezakaKazuo Chijiiwa

❮ Previous
Next ❯

Citations

Jun 7, 2017·Current Problems in Surgery·Najjia N MahmoudJohn P Fischer
Sep 19, 2018·Alimentary Pharmacology & Therapeutics·Shaji SebastianGionata Fiorino
Apr 25, 2020·World Journal of Gastroenterology : WJG·Xue-Liang SunBo-Lin Yang
Feb 28, 2016·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·E Joline de GroofChristianne J Buskens

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
Bo-lin YangYun-fei Gu
Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Guillaume BouguenLaurent Peyrin-Biroulet
Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Konstantinos KarmirisGert Van Assche
© 2022 Meta ULC. All rights reserved