Long-term outcome of islet transplantation on insulin-dependent diabetes mellitus: An observational cohort study

Journal of Diabetes Investigation
Toshihiro NakamuraNobuya Inagaki

Abstract

To investigate the long-term efficacy and safety of islet transplantation (ITx) compared with multiple daily injections (MDI) or continuous subcutaneous insulin infusion (CSII). Among 619 patients diagnosed as insulin-dependent diabetes mellitus or type 1 diabetes at Kyoto University, Kyoto, Japan, seven patients were selected as the ITx group and 26 age-matched patients with no endogenous insulin secretion were selected as the MDI/CSII group. Hemoglobin A1c, aspartate aminotransferase/alanine aminotransferase (AST/ALT) and creatinine were assessed retrospectively at 1, 2, 5 and 10 years for both groups; serum C-peptide immunoreactivity was assessed for the ITx group. Major clinical events were also assessed. Hemoglobin A1c improvement in ITx was significant at 1 year (8.4% [7.8-9.9%] at baseline to 7.1% [6.3-7.4%] in ITx vs 8.2% [7.4-9.8%] at baseline to 8.1% [7.3-9.5%] in MDI/CSII, P < 0.01 between groups), and was maintained at 2 years (7.4% [6.3-8.2%] vs 8.4% [7.4-9.6%], P = 0.11). The increase of stimulated C-peptide immunoreactivity was significant at 1 year (0.57 ng/mL [0.26-0.99 ng/mL], P < 0.05 from baseline) and 2 years (0.43 ng/mL [0.19-0.67 ng/mL], P < 0.05), although it became insignificant thereafter. There was no...Continue Reading

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Citations

May 21, 2020·Journal of Diabetes Investigation·Toshihiro NakamuraNobuya Inagaki
Jul 13, 2020·Journal of Diabetes Investigation·Toshihiro NakamuraNobuya Inagaki
Nov 29, 2020·Endocrine Reviews·Braulio A Marfil-GarzaA M James Shapiro
Jan 27, 2021·Stem Cells·Phillip L Lewis, James M Wells
Aug 3, 2021·Annals of Gastroenterological Surgery·Yoshito TomimaruTakashi Kenmochi
Aug 28, 2021·Frontiers in Endocrinology·Meghan Tahbaz, Eiji Yoshihara
Jul 22, 2021·Journal of Diabetes Investigation·Moon-Kyu Lee

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