Long-term outcome of medullary thyroid carcinoma in patients with normal postoperative medical imaging

British Journal of Cancer
G PellegritiM Schlumberger

Abstract

Imaging-detected relapses are observed in a significant proportion of patients with medullary thyroid carcinoma (MTC) with normal postoperative imaging studies. The aim of this study was to search for prognostic factors of imaging-detected relapse. This retrospective study was performed in 63 consecutive MTC patients with normal postoperative medical imaging. After surgery, the basal calcitonin (CT) level was undetectable in 35 patients and elevated in 28. During follow-up, 18 patients developed a clinical or imaging-detected relapse (29%) in the neck and/or at distant sites: 15 had an elevated postoperative basal CT level and three had an undetectable postoperative basal CT level. At multivariate analysis, the significant parameters predictive of imaging-detected relapse were the postoperative plasma CT level and the tumour extension (pT). The 3- and 5-year relapse-free survival rates were 94 and 90% in patients with an undetectable postoperative basal CT level, and 78 and 61% in patients with a detectable basal CT level (P<0.05). The 3- and 5-year relapse-free survival rates were 92 and 85% in the pT1-3 patients, and 57 and 46% in the pT4 patients (P<0.01). These results show that postoperative CT level and tumour extension a...Continue Reading

References

Jan 4, 1992·Lancet·R M CouplandL Doswald-Beck
Oct 1, 1988·The Journal of Clinical Endocrinology and Metabolism·N A SamaanR C Hickey
May 1, 1984·The Journal of Clinical Endocrinology and Metabolism·M F SaadN A Samaan
Feb 1, 1983·International Journal of Radiation Oncology, Biology, Physics·P RougierM Tubiana
Jul 29, 1998·Journal of Internal Medicine·J F MoleyS A Wells
Feb 24, 2001·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·S L HyerC Harmer
Aug 21, 2002·Thyroid : Official Journal of the American Thyroid Association·N FershtC Harmer

❮ Previous
Next ❯

Citations

Jul 7, 2007·Thyroid : Official Journal of the American Thyroid Association·Simona Grozinsky-GlasbergMordechai Lapidot
Jul 25, 2008·Thyroid : Official Journal of the American Thyroid Association·Beatriz G CavalheiroLenine G Brandão
May 28, 2009·Thyroid : Official Journal of the American Thyroid Association·UNKNOWN American Thyroid Association Guidelines Task ForceSamuel A Wells
Dec 19, 2015·Critical Reviews in Clinical Laboratory Sciences·Mehdi HedayatiFarinaz Afsari
Feb 4, 2016·Endocrine·Theodora Pappa, Maria Alevizaki
Sep 10, 2004·Clinical Endocrinology·Sophie LeboulleuxMartin Schlumberger
Nov 24, 2006·Clinical Endocrinology·Jan Willem B de GrootThera P Links
Mar 27, 2015·Thyroid : Official Journal of the American Thyroid Association·Samuel A WellsUNKNOWN American Thyroid Association Guidelines Task Force on Medullary Thyroid Carcinoma
Oct 23, 2014·Thyroid : Official Journal of the American Thyroid Association·Susan C LindseyR Michael Tuttle
Nov 5, 2014·Annals of Surgical Oncology·Allen S HoIan Ganly
Apr 15, 2017·Updates in Surgery·Agathoklis KonstantinidisJulie Ann Sosa
Aug 23, 2017·International Journal of Molecular Sciences·Dagmara RusinekBarbara Jarzab
Oct 8, 2017·Annals of Nuclear Medicine·Federico CaobelliUNKNOWN Young AIMN Working Group
Dec 18, 2007·Nature Clinical Practice. Endocrinology & Metabolism·Martin SchlumbergerMassimo Santoro
May 31, 2018·The Journal of Clinical Endocrinology and Metabolism·Luciana Audi CastronevesAna Oliveira Hoff
Jan 9, 2019·Thyroid : Official Journal of the American Thyroid Association·Jes Sloth MathiesenChristian Godballe
May 29, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Rafał CzepczyńskiAlberto Signore
May 21, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Michael LassmannUNKNOWN EANM Dosimetry Committee
Dec 17, 2008·Nature Clinical Practice. Endocrinology & Metabolism·Giuseppe CostanteSebastiano Filetti
Jun 16, 2009·Journal of Internal Medicine·W van VeelenC J M Lips
Dec 2, 2009·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Trond Velde BogsrudVal J Lowe
Oct 26, 2010·ANZ Journal of Surgery·Deepak AbrahamStan Sidhu
Jan 10, 2012·European Journal of Nuclear Medicine and Molecular Imaging·Giorgio TregliaVittoria Rufini
Sep 23, 2014·Annals of Surgical Oncology·Kathryn J RowlandJeffrey F Moley
Feb 23, 2012·Journal of Surgical Oncology·Lai XuHong Shu
May 31, 2019·The Journal of Clinical Endocrinology and Metabolism·Friedhelm RaueKarin Frank-Raue
Mar 22, 2013·Thyroid Research·Johannes Smit
Jan 12, 2020·Endocrine·Giuseppe Costante, Domenico Meringolo
Sep 1, 2009·Expert Review of Endocrinology & Metabolism·Cornelis Jm LipsJo Wm Höppener
Aug 30, 2007·The Journal of Clinical Endocrinology and Metabolism·Anne Laure GiraudetMartin Schlumberger
Mar 12, 2020·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Lili ChenZhuoying Wang
Jan 1, 2008·Biomarker Insights·Rosaria M RuggeriMaria Trovato
Jun 15, 2017·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Ji H YangRui M B Maciel
Apr 5, 2012·Nature Reviews. Endocrinology·Rossella Elisei, Aldo Pinchera
Oct 20, 2015·Journal of Pediatric Hematology/oncology·Vidya K NarayananMohamad G Shaikh

❮ Previous
Next ❯

Methods Mentioned

BETA
surgical resection
dissection

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of the Formosan Medical Association = Taiwan Yi Zhi
Min-Huang HsiehTien-Chun Chang
Journal of Cutaneous Pathology
Catherine NashedRonald Scott Chamberlain
Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society
J M JimenezA Khan
© 2022 Meta ULC. All rights reserved