Long-term outcome of patients undergoing liver transplantation for mixed hepatocellular carcinoma and cholangiocarcinoma: an analysis of the UNOS database

HPB : the Official Journal of the International Hepato Pancreato Biliary Association
Valery VilchezErin Maynard

Abstract

Mixed hepatocellular and cholangiocarcinoma (HCC-CC) have been associated with a poor prognosis after liver transplantation (LT). We aimed to evaluate long-term outcomes in patients undergoing LT for HCC-CC versus patients with hepatocellular carcinoma (HCC) or cholangiocarcinoma (CC). Retrospective analysis of the United Network for Organ Sharing (UNOS) database from 1994-2013. Overall survival (OS) in patients with HCC-CC, HCC, and CC, were compared. We identified 4049 patients transplanted for primary malignancy (94 HCC-CC; 3515 HCC; 440 CC). Mean age of patients with HCC-CC was 57 ± 10 years, and 77% were male. MELD score did not differ among the groups (p = 0.637). Hepatitis C virus was the most common secondary diagnosis within the HCC-CC (44%) and HCC (36%) cohorts, with primary sclerosing cholangitis in the CC (16%) cohort. OS rates at 1, 3 and 5 years for HCC-CC (82%, 47%, 40%) were similar to CC (79%, 58%, 47%), but significantly worse than HCC (86%, 72%, and 62% p = 0.002). Patients undergoing LT for HCC had significantly better survival compared to those transplanted for HCC-CC and CC. LT for mixed HCC-CC confers a survival rate similar to selected patients with CC. Efforts should be made to identify HCC-CC patients...Continue Reading

References

Aug 1, 1996·Journal of Gastroenterology and Hepatology·J TaguchiM Kojiro
Sep 16, 1998·Journal of Gastroenterology and Hepatology·I O NgL T Ma
Sep 24, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Debra SudanAlan Langnas
Jan 7, 2003·Archives of Surgery·Chi-Leung LiuJohn Wong
Aug 13, 2003·Japanese Journal of Clinical Oncology·Yoshiko YanoMasatoshi Makuuchi
Sep 24, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Julie K HeimbachGregory J Gores
May 4, 2007·Asian Journal of Surgery·Albert Chi-Yan ChanSheung Tat Fan
Apr 28, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C PanjalaD M Harnois
May 26, 2010·Transplant International : Official Journal of the European Society for Organ Transplantation·Charles B RosenGregory J Gores
Aug 3, 2010·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Eric J Grossman, J Michael Millis
Mar 26, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Gonzalo SapisochinFrancis Y Yao
Jul 12, 2011·Journal of Hepato-biliary-pancreatic Sciences·Qian ZhanHong-Wei Li
Aug 3, 2011·Nature Reviews. Gastroenterology & Hepatology·Boris BlechaczGregory J Gores
Feb 7, 2013·Journal of Surgical Oncology·Ryan T GroeschlT Clark Gamblin
Jan 1, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·W R KimB L Kasiske
Mar 4, 2014·Lancet·Nataliya Razumilava, Gregory J Gores
Sep 17, 2014·Gastroenterology·Philipp DutkowskiPierre-Alain Clavien

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Citations

Aug 23, 2016·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·John R BergquistRory L Smoot
Oct 19, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Roman ZenouziChristoph Schramm
Dec 28, 2016·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Dong-Hwan JungSung-Gyu Lee
Mar 8, 2018·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·David D LeeDenise M Harnois
Mar 16, 2017·World Journal of Hepatology·Shweta GeraRuliang Xu
Nov 11, 2017·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Benedikt SchaeferStefan Schneeberger
Mar 25, 2018·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Keri E LunsfordVatche G Agopian
Apr 1, 2020·Cancers·Simona LeoniFabio Piscaglia
Feb 25, 2020·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Eleonora De MartinEric Vibert
Jun 1, 2020·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Ioannis A ZiogasSophoclis P Alexopoulos
Apr 17, 2020·Current Oncology Reports·Guergana G PanayotovaKeri E Lunsford
Oct 13, 2017·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Nicolás GoldaracenaGonzalo Sapisochin
Nov 16, 2019·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Yi-Hsuan ChuangYu-Fan Cheng
Sep 24, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Elia GiganteValérie Paradis
May 18, 2016·World Journal of Gastroenterology : WJG·An-Qiang WangHai-Tao Zhao
Feb 11, 2020·JHEP Reports : Innovation in Hepatology·Phillipe AbreuGonzalo Sapisochin
Sep 12, 2020·The Innovation·Mei FengShaokun Shu
Mar 3, 2021·Current Opinion in Organ Transplantation·Chandrashekhar KubalJohn Holden
Mar 28, 2021·Journal of the American College of Surgeons·Christopher M Jones
Aug 6, 2020·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Dimitrios SchizasEvangelos Felekouras
Jun 15, 2021·World Journal of Gastrointestinal Surgery·Guergana PanayotovaNikolaos Pyrsopoulos
Mar 19, 2019·Transplantation Proceedings·N MachairasG C Sotiropoulos
Aug 10, 2021·World Journal of Gastroenterology : WJG·Nikolaos FragkouEmmanouil Sinakos

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