Long-term outcome of patients with bipolar disorder commenced on lithium prophylaxis during hospitalization: a complete 15-year register-based follow-up

Bipolar Disorders
Rasmus W LichtArne Brodersen

Abstract

From placebo-controlled studies of up to two years duration, it has been established that lithium has preventive efficacy in bipolar disorder (BD). However, the effectiveness of lithium under routine conditions seems less pronounced. In the present study, the overall 15.3-year outcome in BD patients commenced on lithium is described. Ninety-one patients with BD consecutively commenced on prophylactic lithium treatment during hospitalization at the Aarhus University Psychiatric Hospital from 1981 to 1983 were followed until death or censoring occurred during up to 15.3 years of observation. Register-based outcome measures, available for all patients, included accumulated duration of admission and number of admissions. In addition, serious attempts were made to collect detailed information on treatment during follow up. Simple descriptive statistics were applied; potential independent associations between baseline variables and outcome were examined using logistic regression models. Of the 91 patients, 27 patients died (six from suicide) during the observation period, which was an excess mortality compared to the general population. Fifty percent of the patients were admitted for more than one month per 20 months of observation a...Continue Reading

References

Jul 1, 1990·Archives of General Psychiatry·M HarrowH Y Meltzer
Apr 1, 1990·Archives of General Psychiatry·W H BerrettiniS Detera-Wadleigh
Jan 1, 1972·Archives of General Psychiatry·J P FeighnerR Munoz
Feb 9, 2000·Archives of General Psychiatry·R J Baldessarini, L Tondo
Jul 27, 2000·The British Journal of Psychiatry : the Journal of Mental Science·A BrodersenP B Mortensen
Nov 28, 2001·Acta Psychiatrica Scandinavica·R W LichtP E Hansen
Mar 22, 2003·European Psychiatry : the Journal of the Association of European Psychiatrists·Vanessa RaymontSophia Frangou
Mar 27, 2003·Bipolar Disorders·Elliot D Luby, Ravi Kumar Singareddy
Sep 17, 2003·Acta Psychiatrica Scandinavica. Supplementum·R W LichtUNKNOWN Danish Psychiatric Association and the Child and Adolescent Psychiatric Association in Denmark
Jan 20, 2004·The Journal of Clinical Psychiatry·Ralph W KupkaWillem A Nolen
Sep 4, 2004·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Heinz GrunzeUNKNOWN WFSBP Task Force on Treatment Guidelines for Bipolar Disorders
Jun 15, 2005·Bipolar Disorders·Lakshmi N YathamUNKNOWN Canadian Network for Mood and Anxiety Treatments
Feb 2, 2006·The American Journal of Psychiatry·J Raymond DePaulo

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Citations

Jan 1, 2013·International Journal of Bipolar Disorders·Anne BerghöferAndrea Pfennig
Mar 10, 2011·Expert Opinion on Pharmacotherapy·Steven L Dubovsky, Amelia N Dubovsky
Nov 11, 2011·CNS Neuroscience & Therapeutics·Rasmus W Licht
Jun 13, 2013·Bipolar Disorders·Maurizio PompiliPaolo Girardi
Jun 7, 2014·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Covadonga M Díaz-CanejaDolores Moreno
Mar 14, 2013·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Heinz GrunzeUNKNOWN WFSBP Task Force on Treatment Guidelines for Bipolar Disorders
Apr 9, 2016·Expert Review of Neurotherapeutics·Ludovic SamalinEduard Vieta
Jun 20, 2018·Bipolar Disorders·Anastasiya NestsiarovichChristophe G Lambert
Feb 21, 2014·Interactive Journal of Medical Research·Valentina IsettaJosep M Montserrat
Jun 23, 2009·Bipolar Disorders·Paul Grof, Bruno Müller-Oerlinghausen
May 13, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Rosamond RhodesThomas D Schiano
Apr 3, 2021·Therapeutic Advances in Psychopharmacology·Mutahira M Qureshi, Allan H Young

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