Long-Term Outcome of Patients With Chronic Thromboembolic Pulmonary Hypertension: Results From an International Prospective Registry

Circulation
Marion DelcroixGérald Simonneau

Abstract

Chronic thromboembolic pulmonary hypertension, a rare complication of acute pulmonary embolism, is characterized by fibrothrombotic obstructions of large pulmonary arteries combined with small-vessel arteriopathy. It can be cured by pulmonary endarterectomy, and can be clinically improved by medical therapy in inoperable patients. A European registry was set up in 27 centers to evaluate long-term outcome and outcome correlates in 2 distinct populations of operated and not-operated patients who have chronic thromboembolic pulmonary hypertension. A total of 679 patients newly diagnosed with chronic thromboembolic pulmonary hypertension were prospectively included over a 24-month period. Estimated survival at 1, 2, and 3 years was 93% (95% confidence interval [CI], 90-95), 91% (95% CI, 87-93), and 89% (95% CI, 86-92) in operated patients (n=404), and only 88% (95% CI, 83-91), 79% (95% CI, 74-83), and 70% (95% CI, 64-76) in not-operated patients (n=275). In both operated and not-operated patients, pulmonary arterial hypertension-targeted therapy did not affect survival estimates significantly. Mortality was associated with New York Heart Association functional class IV (hazard ratio [HR], 4.16; 95% CI, 1.49-11.62; P=0.0065 and HR, ...Continue Reading

References

Aug 3, 1999·American Journal of Respiratory and Critical Care Medicine·C J ArchibaldK M Moser
Nov 7, 2003·The Annals of Thoracic Surgery·Stuart W JamiesonWilliam R Auger
Apr 16, 2004·The European Respiratory Journal·P BresserL J Rubin
Feb 27, 2007·Journal of Thrombosis and Haemostasis : JTH·N Skoro-SajerI M Lang
Apr 4, 2007·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Ségolène CabrolOlivier Sitbon
Feb 23, 2008·American Journal of Respiratory and Critical Care Medicine·Robin CondliffeJoanna Pepke-Zaba
Jun 17, 2008·American Journal of Respiratory and Critical Care Medicine·Angelo G CorsicoMario Viganò
Sep 19, 2008·The European Respiratory Journal·D BondermanI M Lang
Dec 20, 2008·Journal of the American College of Cardiology·Xavier JaïsUNKNOWN Bosentan Effects in iNopErable Forms of chronIc Thromboembolic pulmonary hypertension Study Group
Feb 24, 2009·Respiratory Medicine·Nabil SaoutiAnton Vonk Noordegraaf
Mar 11, 2009·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Nabil SaoutiRepke J Snijder
Aug 8, 2009·The Journal of Thoracic and Cardiovascular Surgery·Herre J ReesinkPaul Bresser
Feb 22, 2011·The Journal of Thoracic and Cardiovascular Surgery·Eckhard MayerPhilippe Dartevelle
Jun 16, 2012·The European Respiratory Journal·Irene M LangJason X-J Yuan
Nov 13, 2012·The European Respiratory Journal·David P JenkinsPhilippe Dartevelle
Jul 26, 2013·The New England Journal of Medicine·Hossein-Ardeschir GhofraniUNKNOWN CHEST-1 Study Group
Dec 21, 2013·Journal of the American College of Cardiology·Nick H KimEckhard Mayer
May 31, 2014·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Maria WieteskaAdam Torbicki
Aug 6, 2014·Circulation·Irene Marthe Lang, Michael Madani
Aug 19, 2014·The Journal of Thoracic and Cardiovascular Surgery·Andrea M D'ArminiRoberto Dore

❮ Previous
Next ❯

Citations

Mar 8, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Manabu Horii
Apr 14, 2016·The Lancet. Respiratory Medicine·Heinrike Wilkens, Matthias Held
May 14, 2016·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·David W M Muller, Christoph Liebetrau
Aug 30, 2016·Annals of the American Thoracic Society·Michael MadaniDavid P Jenkins
Aug 30, 2016·Annals of the American Thoracic Society·Joanna Pepke-ZabaRichard Channick
Sep 30, 2016·Heart·J E Cannon, J Pepke-Zaba
Jan 5, 2018·Interactive Cardiovascular and Thoracic Surgery·Tom VerbelenBart Meyns
Apr 3, 2018·Journal of Thrombosis and Haemostasis : JTH·F A KlokH J Bogaard
Jan 27, 2018·Interactive Cardiovascular and Thoracic Surgery·Jason M AliDavid P Jenkins
Jun 22, 2018·PloS One·Cécile TromeurElie Fadel
Mar 14, 2018·American Journal of Respiratory and Critical Care Medicine·Evan L BrittainPaul B Yu
Aug 14, 2018·Journal of Thrombosis and Haemostasis : JTH·Y M Ende-VerhaarF A Klok
Jan 9, 2018·Pulmonary Circulation·John Gerry Coghlan
Oct 22, 2016·Circulation. Cardiovascular Interventions·Jane A Leopold
Jan 27, 2017·Circulation·Emelia J BenjaminUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Feb 2, 2018·Circulation·Emelia J BenjaminUNKNOWN American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee
Feb 1, 2019·Circulation·Emelia J BenjaminUNKNOWN American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee
Feb 6, 2019·Journal of Cardiovascular Medicine·Stefano AlbaniGianfranco Sinagra
Feb 1, 2019·The Cochrane Database of Systematic Reviews·Hayley BarnesTrevor Williams
Feb 9, 2019·Transplant International : Official Journal of the European Society for Organ Transplantation·Janne BrouckaertDirk Van Raemdonck
Dec 22, 2017·European Respiratory Review : an Official Journal of the European Respiratory Society·Michael MadaniGérald Simonneau
Jul 14, 2018·The European Respiratory Journal·Syed Rehan QuaderyDavid G Kiely
Sep 18, 2018·The European Respiratory Journal·Nick H Kim, Eckhard Mayer
Jan 12, 2019·The European Respiratory Journal·Robin CondliffeDavid G Kiely
Oct 20, 2018·The European Respiratory Journal·Marion DelcroixMarius M Hoeper
Mar 17, 2017·European Respiratory Review : an Official Journal of the European Respiratory Society·David JenkinsEckhard Mayer
Mar 31, 2017·European Respiratory Review : an Official Journal of the European Respiratory Society·Irene LangPhilippe Brenot
Mar 31, 2017·European Respiratory Review : an Official Journal of the European Respiratory Society·Henning GallEckhard Mayer
Mar 31, 2017·European Respiratory Review : an Official Journal of the European Respiratory Society·Joanna Pepke-ZabaMarius M Hoeper
Dec 14, 2018·The European Respiratory Journal·Nick H KimDavid P Jenkins
Jan 19, 2019·The European Respiratory Journal·Michael NewnhamMark Toshner
Apr 27, 2019·The European Respiratory Journal·Philippe BrenotGérald Simonneau

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