Long-term outcome of patients with frequently recurrent non-muscle-invasive bladder carcinoma treated with one perioperative plus four weekly instillations of mitomycin C followed by monthly bacillus Calmette-Guérin (BCG) or alternating BCG and interferon-α2b instillations: prospective randomised FinnBladder-4 study

European Urology
Riikka JärvinenFinnBladder Group

Abstract

Recurrent TaT1 non-muscle-invasive bladder cancer (NMIBC) patients should be treated with immediate instillation of chemotherapy after transurethral resection of bladder tumour followed by instillation therapy. To present long-term results of a study exploring the effect of initial mitomycin C (MMC) instillations followed by two types of immunotherapy for patients with frequently recurring NMIBC. Between 1992 and 1996, 236 patients with frequently recurring TaT1 grade 1-2 NMIBC were enrolled in the prospective randomised multicentre FinnBladder-4 study. One perioperative plus four weekly instillations of MMC followed by monthly bacillus Calmette-Guérin (BCG) or alternating BCG and interferon (IFN)-α2b instillations for up to 1 yr. Primary end points were time to first recurrence and time to progression. Secondary end points were disease-specific mortality and overall survival. The principal statistical methods were the proportional subdistribution hazards model and Cox proportional hazards model plus cumulative incidence and Kaplan-Meier analyses. The median follow-up was 10.3 yr (maximum: 19.8 yr) in the MMC-BCG group and 8.6 yr (maximum: 19.8 yr) in the MMC-BCG/IFN group. The probability of recurrence was significantly lower ...Continue Reading

Citations

Feb 11, 2016·Immunotherapy·Sean G Smith, David A Zaharoff
Apr 9, 2016·Oncoimmunology·Erika VacchelliLorenzo Galluzzi
Apr 22, 2015·European Urology·Robert S Svatek
Jun 22, 2016·European Urology·Marko BabjukRichard Zigeuner
Jan 8, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hui GuoXuesi Chen
Jun 2, 2016·Therapeutic Advances in Urology·Akhil MuthigiPiyush K Agarwal
Jan 9, 2020·The Cochrane Database of Systematic Reviews·Stefanie SchmidtJoerg J Meerpohl

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