Long-term outcome of patients with prostate cancer and pathologic seminal vesicle invasion (pT3b): effect of adjuvant radiotherapy

Urology
Heather M LeeRichard K Valicenti

Abstract

To evaluate the long-term outcome of patients with prostate cancer who have pathologic seminal vesicle invasion without lymph node metastasis (pT3bN0M0) and compare management strategies. From October 1987 to August of 1997, 43 men underwent radical prostatectomy at Thomas Jefferson University Hospital, had pT3bN0M0 disease, complete preoperative and postoperative prostate-specific antigen (PSA) data, and a minimum of 2 years of follow-up. Eighteen patients with undetectable postoperative PSA levels received adjuvant radiotherapy (RT) within 6 months of surgery. Twelve patients with undetectable PSA levels postoperatively were considered for salvage treatment at biochemical progression. Thirteen patients with persistently elevated PSA levels postoperatively underwent immediate salvage RT. We evaluated the prognostic factors for freedom from biochemical failure (bNED), distant metastasis (DM), disease-specific survival, and overall survival. The median follow-up time was 5.9 years (range 2 to 10). Patients who received adjuvant RT had significantly greater 5-year bNED survival than patients who did not (80% versus 8%, P <0.001) and increased freedom from DM that was of borderline significance (P = 0.05). The 5-year survival esti...Continue Reading

References

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Citations

May 28, 2013·The Journal of Urology·Ian M ThompsonMartha M Faraday
May 4, 2011·International Journal of Radiation Oncology, Biology, Physics·Sinisa StanicRichard K Valicenti
Apr 29, 2009·Surgical Oncology·Charlotte L Foley, Mark R Feneley
Sep 25, 2007·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·A Bossi
May 16, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·G FranciniR Petrioli
Aug 20, 2011·BJU International·Cyrille BastideAntoine Van Hove
Aug 14, 2012·International Journal of Surgical Oncology·Alexander I HinevVesselin I Hadjiev
Jul 13, 2013·International Journal of Radiation Oncology, Biology, Physics·Richard K ValicentiUNKNOWN American Society for Radiation Oncology/American Urological Association
Sep 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Theodorus H Van der KwastUNKNOWN EORTC 22911
Nov 10, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Matthew R CooperbergPeter R Carroll
Jan 29, 2011·American Journal of Clinical Oncology·Carl J RossiGregory Merrick
Jun 5, 2020·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·C H Flores-BalcázarF Rodríguez-Covarrubias

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