Long-term outcome of preadolescents, adolescents, and adult patients undergoing total cavopulmonary connection

The Journal of Thoracic and Cardiovascular Surgery
Masamichi OnoRüdiger Lange

Abstract

Patients with a single ventricle infrequently undergo total cavopulmonary connection as preadolescents, adolescents, or adults. The purpose of this study was to clarify the characteristics of this cohort and to analyze the factors influencing outcomes. Between 1994 and 2015, 50 of 460 patients underwent total cavopulmonary connection as preadolescents, adolescents, or adults (group A). The patients' characteristics and operative results were compared with those of the remaining 410 patients aged less than 9 years who underwent total cavopulmonary connection (group B). Post-total cavopulmonary connection echocardiogram reports (n = 4862) were used to evaluate longitudinal ventricular function, and ejection fraction was characterized using nonlinear mixed-effects models and compared between groups. The median follow-up time was 10.3 (2.8-15.5) years. The differences between groups in 30-day mortality (P = .20), intensive care unit stay (P = .20), and incidence of prolonged effusion (P = .08) were not significant. The estimated survival at 15 years was lower in group A (86.5%) than in group B (94.0%, P = .04) patients. Long-term systemic ventricular ejection fraction, analyzed with linear mixed-effect models, was significantly red...Continue Reading

Citations

Jul 26, 2019·Pediatric Cardiology·Keti VitanovaMasamichi Ono
Mar 11, 2021·Seminars in Thoracic and Cardiovascular Surgery·Masamichi OnoRüdiger Lange
Dec 24, 2018·The Journal of Thoracic and Cardiovascular Surgery·Masamichi OnoRüdiger Lange

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