Long-term outcome of transplant renal artery stenosis managed conservatively or by radiological intervention

Clinical Transplantation
Colin C GeddesGrant M Baxter

Abstract

The natural history and optimal treatment of transplant renal artery stenosis (TRAS) is poorly defined. Few studies reported long-term clinical outcomes. A single centre analysis of 43 patients diagnosed with TRAS 1990-2003 was performed. Twenty-seven had percutaneous intervention (including 10 patients who had >1 intervention) and 16 were managed conservatively at the discretion of the attending clinicians. Transplant function was assessed by slope of estimated glomerular filtration rate (eGFR) over five yr of follow-up. Patients in the intervention group had lower mean eGFR (36.3 mL/min/1.73 m(2) vs. 46.3 mL/min/1.73 m(2); p = 0.07) at baseline. Five transplants in the intervention group failed (including two as a direct result of intervention) and one in the conservative group failed. There was no significant difference in the rate of deterioration in renal function (mean slope of eGFR minus 0.8 mL/min/yr and minus 1.0 mL/min/yr in the intervention and conservative groups, respectively; p = 0.79). There was no significant difference in blood pressure or number of anti-hypertensive agents between the groups at any time point. Baseline Doppler ultrasound indices showed no significant correlation with slope of eGFR in either gr...Continue Reading

References

Dec 12, 1997·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·G M Baxter, R S Rodger
Feb 15, 2001·The New England Journal of Medicine·J RadermacherH Haller
Jun 26, 2001·Kidney International·P RuggenentiG Remuzzi
Jun 21, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jadranka Buturović-Ponikvar
Dec 25, 2003·Journal of the American Society of Nephrology : JASN·Simona BrunoPiero Ruggenenti
May 13, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Bertram L KasiskeDavid Rush
Jun 10, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Adina VoiculescuBernd Grabensee
Jun 22, 2005·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Ana Zupunski, Jadranka Buturović-Ponikvar
Jan 26, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·V AudardP Grimbert
Mar 1, 2006·Transplantation Proceedings·W G PolakM Klinger

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Citations

Feb 25, 2014·Cardiovascular and Interventional Radiology·Minhaj S KhajaWael E Saad
Dec 25, 2013·Journal of Vascular Surgery·Joseph ToumaMyriam Combes
Nov 28, 2012·Journal of Vascular and Interventional Radiology : JVIR·Boris NikolicWael A Saad
Mar 1, 2012·Actas urologicas españolas·C OchoaH Villavicencio
Jan 13, 2011·Advances in Chronic Kidney Disease·Mario F Rubin
Dec 17, 2009·Techniques in Vascular and Interventional Radiology·Wade HedegardMark G Davies
Jul 24, 2012·Transplant International : Official Journal of the European Society for Organ Transplantation·Thomas BessedeGerard Benoit
Feb 24, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D M BiedermanR A Lookstein
Sep 20, 2016·Techniques in Vascular and Interventional Radiology·Kanti Pallav Kolli, Jeanne M LaBerge
Mar 24, 2017·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Xufeng ZhangChuan Tian
Aug 5, 2010·Angiology·Arash SeratnahaeiDebabrata Mukherjee
Dec 10, 2019·Pediatric Transplantation·Sudha MannemuddhuKiran Upadhyay
Dec 6, 2019·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Yanqiao RenChuansheng Zheng
Feb 3, 2018·Clinical Transplantation·Ling-Xin ChenGhaneh Fananapazir
Aug 18, 2021·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·David Eugenio Hinojosa-GonzalezEduardo Flores-Villalba
May 7, 2009·The Canadian Journal of Cardiology·G V Ramesh PrasadMarcel Lebel

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