Long-term outcome, survival and predictors of mortality after MitraClip therapy: Results from the German Transcatheter Mitral Valve Interventions (TRAMI) registry

International Journal of Cardiology
Daniel KalbacherEdith Lubos

Abstract

MitraClip therapy is increasingly used in patients deemed inoperable to treat severe mitral regurgitation (MR), but long-tern data is scarce. The multicentre, industry-independent German Transcatheter Mitral Valve Interventions (TRAMI) registry comprises the largest prospectively enrolled cohort of patients treated by MitraClip therapy. The current analysis is focusing on long-term mortality rates, cardiac rehospitalization and reintervention. Long-term follow-up (median time 1037 days) in the TRAMI registry was available for 722 patients treated at 20 German centres. Improvements in New York Heart Association (NYHA) functional class (I/II long-term: 65% vs. 1-year follow-up: 63.3%) and self-rated health-status (EuroQuol visual analogue scale [EQ VAS] long-term: 60 [50-70] vs. 1-year follow-up: 60 [50; 70]) were pertained over time. Estimated mortality rates by Kaplan-Meier method were 19.7% for 1-year, 31.9% for 2-year and 53.1% for 4-year follow-up without differences found for MR aetiology. Multivariable Cox-regression analysis identified previous aortic valve implantation (hazard ratio [HR] = 2.21; p < 0.0001), NYHA class IV (HR = 1.78; p < 0.001), prior cardiac decompensation (HR = 1.63; p < 0.001), creatinine > 1.5 mg/dl ...Continue Reading

Citations

Apr 9, 2020·European Journal of Heart Failure·Daniel ReichartEdith Lubos
Jun 13, 2020·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Martin GeyerRalph Stephan von Bardeleben
Feb 6, 2020·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Daniel SürderUNKNOWN Collaborators
Aug 10, 2020·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Muhammad U KhanEdo Kaluski
Dec 29, 2018·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Nicola BuzzattiOttavio Alfieri
Jun 17, 2020·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Hüseyin Ince, Giuseppe D'Ancona
Jan 7, 2020·Innovations : Technology and Techniques in Cardiothoracic and Vascular Surgery·Hunbo ShimTsuyoshi Kaneko
Oct 10, 2020·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Marianna Adamo, Marco Metra
Nov 20, 2020·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Atsushi SugiuraJan-Malte Sinning
Dec 7, 2020·ESC Heart Failure·Aikaterini ChristidiPatrick Horn
Jan 13, 2021·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Martin GeyerRalph Stephan von Bardeleben
Feb 1, 2021·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Christos IliadisRoman Pfister
Jan 19, 2021·IJC Heart & Vasculature·Michael PaukovitschSinisa Markovic
Jan 20, 2020·JACC. Cardiovascular Interventions·Michael MehrUNKNOWN TriValve and TRAMI Investigators
Nov 18, 2020·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Tomás Benito-GonzálezFelipe Fernández-Vázquez
Mar 24, 2021·The Canadian Journal of Cardiology·Nir Levi, David Meerkin
Jul 14, 2021·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Tetsu TanakaMarc Ulrich Becher
Aug 3, 2021·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Ilias P DoulamisGilbert H L Tang

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