Long-term outcomes and patterns of tumor progression after gamma knife radiosurgery for benign meningiomas

Neurosurgery
Gabriel ZadaMichael L J Apuzzo

Abstract

To characterize the timing and patterns of long-term treatment failure after Gamma Knife radiosurgery (GKRS) for benign meningiomas. Data were retrospectively reviewed in 116 patients who underwent 136 GKRS treatments for benign intracranial meningiomas from 1996 to 2004. Patients with atypical or malignant meningiomas were excluded. Surgical resection preceded GKRS in 72 patients (62%). The median tumor volume was 3.4 cm, and the median prescription dose to the 50% isodose line was 16 Gy. The median follow-up time was 75 months (range, 4-146 months). Overall tumor control was achieved in 128 of 136 lesions (94%), of which tumor size was stable in 68% and decreased in 26%. Seven patients experienced disease progression in 8 tumors, occurring at a mean time of 90 months. The overall 5-year and 10-year actuarial tumor control rate was 98.9% and 84%, respectively. Characteristics corresponding to tumor progression included insufficient tumor coverage (98% vs 93%, P = .007), cavernous sinus lesions, and meningiomatosis. Complications after GKRS developed in 8% of patients, in whom the mean tumor volume was nearly double that in patients with no adverse effects (11 vs 5.7 cm3, P = .003). GKRS demonstrates excellent long-term tumor c...Continue Reading

References

Oct 23, 1998·Stereotactic and Functional Neurosurgery·G PendlK Feichtinger
Feb 7, 2002·Minimally Invasive Neurosurgery : MIN·A NicolatoA Bricolo
Dec 14, 2004·International Journal of Radiation Oncology, Biology, Physics·Steven J DiBiaseLawrence S Chin
Jan 25, 2005·Journal of Neurosurgery·Guenther C FeiglGerhard A Horstmann
Sep 9, 2005·British Journal of Neurosurgery·Irfan MalikA A Kemeny
Sep 20, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·W KreilG Papaefthymiou
Jan 24, 2007·Journal of Neurosurgery·William T CouldwellOssama Al-Mefty
Aug 19, 2007·Journal of Neurosurgery·Aurelia KollováLadislava Janousková
Oct 17, 2007·Journal of Neurosurgery·Toshinori HasegawaDai Ishii
Oct 27, 2007·Neurosurgical Focus·Laurence DavidsonSteven L Giannotta
Feb 28, 2008·Neurosurgery·Douglas KondziolkaJohn C Flickinger
Oct 17, 2008·International Journal of Radiation Oncology, Biology, Physics·Jung Ho HanHee-Won Jung
Nov 4, 2008·Journal of Neurosurgery·Yoshiyasu IwaiHidetoshi Ikeda

❮ Previous
Next ❯

Citations

Apr 14, 2011·Radiation Oncology·Giuseppe MinnitiRiccardo Maurizi Enrici
Jul 3, 2013·Journal of Neurosurgery·Bruce E PollockRobert L Foote
Dec 3, 2013·Neurosurgical Focus·Daniel R KlingerSamuel L Barnett
Mar 26, 2016·Neurosurgery Clinics of North America·Or Cohen-InbarJason P Sheehan
Aug 28, 2012·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·G NoëlZ Jastaniah
Jul 15, 2015·Journal of Neurosurgery·Gillian HarrisonDouglas Kondziolka
Jul 4, 2015·Journal of Neurosurgery·Alireza MansouriGelareh Zadeh
Nov 26, 2015·American Journal of Clinical Oncology·Rajni A SethiJohn G Golfinos
Apr 17, 2016·International Journal of Radiation Oncology, Biology, Physics·Frederik Vernimmen
Jul 15, 2015·Acta neurochirurgica·Hai XueTiit Mathiesen
Mar 10, 2015·Journal of Neurosurgery·Rabih AboukaisNicolas Reyns
Oct 25, 2014·Journal of Neurosurgery·Leland RogersMichael A Vogelbaum
Oct 1, 2015·Neurosurgery·Or Cohen-InbarJason P Sheehan
Apr 24, 2014·American Journal of Clinical Oncology·Douglas KondziolkaL Dade Lunsford
Nov 7, 2016·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Lawrance K ChungIsaac Yang
Oct 19, 2011·Journal of Neuro-oncology·Orin BlochIgor J Barani
Feb 20, 2020·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Kiyoshi NakazakiMasaaki Uno
Mar 18, 2021·World Neurosurgery·Amr M N El-ShehabySameh R Tawadros
Mar 24, 2020·Clinical Oncology : a Journal of the Royal College of Radiologists·P PouT Khalil

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Neurosurgery
Jonathan M BledsoeBruce E Pollock
Journal of Neurosurgery
Thomas J FlanneryDouglas Kondziolka
Journal of Neurosurgery
Aurelia KollováLadislava Janousková
International Journal of Radiation Oncology, Biology, Physics
Kotaro NakayaL Dade Lunsford
© 2021 Meta ULC. All rights reserved