Long-term outcomes for heart failure patients with and without diabetes: From the Get With The Guidelines-Heart Failure Registry.

American Heart Journal
Boback ZiaeianGregg C Fonarow

Abstract

Diabetes mellitus is an increasingly prevalent condition among heart failure (HF) patients. The long-term morbidity and mortality among patients with and without diabetes with HF with reduced (HFrEF), borderline (HFbEF), and preserved ejection fraction (HFpEF) are not well described. Using the Get With The Guidelines (GWTG)-HF Registry linked to Centers for Medicare & Medicaid Services claims data, we evaluated differences between HF patients with and without diabetes. Adjusted Cox proportional-hazard models controlling for patient and hospital characteristics were used to evaluate mortality and readmission outcomes. A cohort of 86,659 HF patients aged ≥65 years was followed for 3 years from discharge. Unadjusted all-cause mortality was between 4.4% and 5.5% and all-cause hospitalization was between 19.4% and 22.6% for all groups at 30 days. For all-cause mortality at 3 years from hospital discharge, diabetes was associated with an adjusted hazard ratio of 1.27 (95% CI 1.07-1.49, P = .0051) for HFrEF, 0.95 (95% CI 0.55-1.65, P = .8536) for HFbEF, 1.02 (95% CI 0.87-1.19, P = .8551) for HFpEF. For all-cause readmission, diabetes was associated with an adjusted hazard ratio of 1.06 (95% CI 0.87-1.29, P = .5585) for HFrEF, 1.48 (95...Continue Reading

References

Jun 27, 2007·Circulation·Sihem Boudina, E Dale Abel
Mar 12, 2011·European Journal of Heart Failure·Prakash C DeedwaniaAli Ahmed
Sep 24, 2014·JAMA : the Journal of the American Medical Association·Linda S GeissEdward W Gregg
Dec 3, 2014·Journal of the American College of Cardiology·Robert J MentzChristopher M O'Connor
Feb 11, 2015·JACC. Heart Failure·Alessandra Dei CasGregg C Fonarow
Mar 10, 2015·Circulation. Heart Failure·Zubin J EapenAdrian F Hernandez
Sep 1, 2015·Circulation·Larry A AllenUNKNOWN American Heart Association’s Get With The Guidelines Heart Failure (GWTG-HF) Investigators
Jan 29, 2016·European Heart Journal·David FitchettUNKNOWN EMPA-REG OUTCOME® trial investigators
Jun 14, 2017·The American Journal of Cardiology·Michael Lehrke, Nikolaus Marx

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Citations

Nov 27, 2019·European Journal of Preventive Cardiology·Marc FerriniVictor Aboyans
Nov 26, 2019·Future Cardiology·Carlos EscobarXavier Garcia-Moll Marimón
Mar 30, 2021·Therapeutic Advances in Cardiovascular Disease·Michael V Genuardi, Paul J Mather
Jul 20, 2021·The American Journal of Cardiology·Harshith S ThyagaturuDaniel Katz
Jan 13, 2022·Journal of Managed Care & Specialty Pharmacy·Phil McEwanKlas Bergenheim

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