Long-term outcomes in antimitochondrial antibody negative primary biliary cirrhosis

Scandinavian Journal of Gastroenterology
Gunnar JuliussonK D Lindor

Abstract

Antimitochondrial antibodies (AMA) are a sensitive and specific marker for primary biliary cirrhosis (PBC). AMAs are present in 95% of patients with PBC. However, 5% do not have AMAs and data on these patients is scarce. We aim to evaluate the long-term outcomes of patients with AMA negative PBC. A retrospective chart review of 71 AMA negative PBC patients. Disease presentation, laboratory results, and clinical endpoints were recorded. AMA negative patients were matched on year of diagnosis to a control group of 71 AMA positive patients. Ninety-six percent of the AMA negative patients were of female gender with a median age at diagnosis of 55 years and a length of follow-up of 7.5 years vs. 86% females, a median age of 56 and a follow-up of 8.3 years in the control group. Mean total bilirubin and alkaline phosphatase levels were 0.7 mg/dL vs. 0.6 and 570 U/L vs 341, in AMA negative vs. AMA positive patients at presentation, respectively (p = NS). AMA negative patients did not differ in terms of age, serum IgM levels, ANA status, or length of follow-up. Notably, AMA negative patients had a significantly reduced survival free of liver-related complications including transplantation and death compared to AMA positive patients (p =...Continue Reading

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Citations

Jan 24, 2018·World Journal of Gastroenterology : WJG·Chui-Wen DengYong-Zhe Li
Aug 3, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Keith D LindorMarlyn Mayo
Jan 24, 2020·Journal of Gastroenterology·David Maxwell Hunter Chascsa, Keith Douglas Lindor
Dec 14, 2016·World Journal of Hepatology·Ying-Qiu Huang
Jun 29, 2021·Digestive Diseases and Sciences·Guilherme Grossi Lopes CançadoUNKNOWN Members of the Brazilian Cholestasis Study Group Consortium
Sep 30, 2021·Clinical Reviews in Allergy & Immunology·Francesca ColapietroElena Generali
Oct 7, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Binu V JohnCynthia Levy

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