Long-term outcomes of a phase II randomized controlled trial comparing intensity-modulated radiotherapy with or without weekly cisplatin for the treatment of locally recurrent nasopharyngeal carcinoma

Chinese Journal of Cancer
Ying GuanFei Han

Abstract

Salvage treatment for locally recurrent nasopharyngeal carcinoma (NPC) is complicated and relatively limited. Radiotherapy, combined with effective concomitant chemotherapy, may improve clinical treatment outcomes. We conducted a phase II randomized controlled trial to evaluate the efficacy of intensity-modulated radiotherapy with concomitant weekly cisplatin on locally recurrent NPC. Between April 2002 and January 2008, 69 patients diagnosed with non-metastatic locally recurrent NPC were randomly assigned to either concomitant chemoradiotherapy group (n = 34) or radiotherapy alone group (n = 35). All patients received intensity-modulated radiotherapy. The radiotherapy dose for both groups was 60 Gy in 27 fractions for 37 days (range 23-53 days). The concomitant chemotherapy schedule was cisplatin 30 mg/m(2) by intravenous infusion weekly during radiotherapy. The median follow-up period of all patients was 35 months (range 2-112 months). Between concomitant chemoradiotherapy and radiotherapy groups, there was only significant difference in the 3-year and 5-year overall survival (OS) rates (68.7% vs. 42.2%, P = 0.016 and 41.8% vs. 27.5%, P = 0.049, respectively). Subgroup analysis showed that concomitant chemoradiotherapy signif...Continue Reading

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Citations

Dec 23, 2016·Chinese Journal of Cancer·Shaodong Hong, Li Zhang
Feb 8, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·You Quan LiMelvin L K Chua
Feb 22, 2018·Journal of Experimental & Clinical Cancer Research : CR·Yuan-Yuan QiangChao-Nan Qian
Jun 16, 2017·Cell Death & Disease·Chun-Mei KuangRan-Yi Liu
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Oct 12, 2018·International Journal of Molecular Sciences·Gan QiaoXiukun Lin

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