Long-term outcomes of acromegaly treated with fractionated stereotactic radiation: case series and literature review

Neuro-oncology Practice
Ryan RhomeSheryl Green

Abstract

Growth hormone (GH)-secreting pituitary adenomas represent an uncommon subset of pituitary neoplasms. Stereotactic radiosurgery (SRS) and fractionated stereotactic radiotherapy (FSRT) have been used as primary or adjuvant treatment. The purpose of this study is to report the long-term tumor control and toxicity from our institution and to perform a systematic literature review of acromegaly patients treated with FSRT. We retrospectively reviewed all patients treated with FSRT (median dose 50.4 Gray [Gy], range 50.4-54 Gy) between 2005 and 2012 who had: 1) GH-secreting adenoma with persistently elevated insulin growth factor-1 (IGF-1) despite medical therapy and 2) clinical follow up >3 years after FSRT. Patients were treated with modern FSRT planning techniques. Biochemical control was defined as IGF-1 normalization. Systematic review of the literature was performed for FSRT in acromegaly. With a median follow-up of 80 months, radiographic control was achieved in all 11 patients and overall survival was 100%. Long-term biochemical control was achieved in 10 patients (90.9%) with either FSRT alone (36.4%) or FSRT with continued medical management (45.5%). No patient experienced new hypopituitarism, cranial nerve dysfunctions, or...Continue Reading

References

Apr 5, 1990·The New England Journal of Medicine·S Melmed
Dec 1, 1993·International Journal of Radiation Oncology, Biology, Physics·E ShawL Martin
Sep 30, 1993·International Journal of Radiation Oncology, Biology, Physics·R B TishlerJ C Flickinger
Aug 3, 2001·International Journal of Radiation Oncology, Biology, Physics·S Milker-ZabelM Wannenmacher
Jul 11, 2002·The Journal of Clinical Endocrinology and Metabolism·Gregorio BrevettiAnnamaria Colao
Jul 6, 2004·International Journal of Radiation Oncology, Biology, Physics·Stefanie Milker-ZabelJürgen Debus
Jun 24, 2006·Neurosurgery Clinics of North America·Dheerendra Prasad
Oct 19, 2006·Neuroendocrinology·Gaetano LombardiAnnamaria Colao
Nov 2, 2006·Pituitary·Massimo Scacchi, Francesco Cavagnini
Nov 7, 2006·International Journal of Radiation Oncology, Biology, Physics·Heath B MackleyJohn H Suh
Feb 24, 2007·Pituitary·Raquel S JalladMarcello D Bronstein
May 31, 2007·Technology in Cancer Research & Treatment·Shearwood McClellandWalter A Hall
Nov 1, 2007·The Journal of Clinical Endocrinology and Metabolism·O M DekkersJ P Vandenbroucke
Sep 13, 2008·Reviews in Endocrine & Metabolic Disorders·G MinnitiM Brada
Jul 28, 2009·Journal of Clinical Epidemiology·David MoherUNKNOWN PRISMA Group
Feb 6, 2010·European Journal of Endocrinology·S RougU Feldt-Rasmussen
Feb 24, 2010·Nature Reviews. Endocrinology·Frederic CastinettiThierry Brue
Oct 5, 2010·Neurosurgical Focus·Isaac YangMarvin Bergsneider
Mar 8, 2011·Archives of Medical Research·Baldomero GonzálezMoisés Mercado
Jun 18, 2011·International Journal of Clinical Practice·P AnagnostisM Kita
Aug 6, 2013·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·P J WilsonR I Smee
Aug 21, 2013·International Journal of Radiation Oncology, Biology, Physics·Julian O KimAlan Nichol
Jan 30, 2014·The Journal of Clinical Endocrinology and Metabolism·Cheng-Chia LeeJason Sheehan
Jan 13, 2015·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Jan Patrick BoströmKlaus Hamm
Aug 8, 2015·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Abd Moain Abu DabrhMohammad Hassan Murad
Oct 23, 2015·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Hiren PattNalini S Shah
Mar 5, 2016·Progress in Molecular Biology and Translational Science·Stefano FraraAndrea Giustina

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