Long-term Outcomes of Adolescent Anorexia Nervosa on Bone

The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine
Jessica MumfordCraig Munns

Abstract

Anorexia nervosa (AN) is a chronic and life-threatening eating disorder that can have a considerable negative impact on the growing skeleton. We hypothesized that the long-term impact on bone health may persist even after normalization of body weight. 41 females (mean age 21.2 ± 2.9 years) with a history of adolescent-onset AN attended a follow-up bone health assessment at 5 years (T5, n = 28) or 10 years (T10, n = 13) after their first AN-related hospital admission. Assessment included dual-energy x-ray absorptiometry measurements of the total body, lumbar spine, and proximal femur, peripheral quantitative computed tomography at the radius and tibia, anthropometric measurements, serum biochemistry, fracture history, and a patient questionnaire. A recovery in body weight and BMI was seen for both the T5 and T10 cohorts (BMI at intake 16.6, BMI at T5-T10 21.2-21.3). Dual-energy x-ray absorptiometry body composition indicated a recovery of fat mass and lean tissue mass. Total BMD was unaffected, but reductions were seen at the femoral neck and arms. Peripheral quantitative computed tomography showed reduced trabecular and cortical bone in the radius, and cortical thinning in the tibia. AN patients showed a statistically significa...Continue Reading

Citations

May 10, 2020·LGBT Health·Rebecca C KamodyChristy L Olezeski
Sep 10, 2020·Journal of Eating Disorders·Morgane MarionElise Launay
Jul 25, 2019·Zeitschrift für Rheumatologie·Christine HofmannFranz Jakob
Nov 14, 2019·Journal of Eating Disorders·Pratibha Anand, Philip S Mehler
Jan 12, 2021·Journal of Eating Disorders·Julia ClarkeRichard Delorme
Mar 28, 2021·The Journal of Clinical Endocrinology and Metabolism·Juliane LégerSophie Guilmin-Crepon
Mar 12, 2021·The Journal of Clinical Endocrinology and Metabolism·Vibha SinghalMadhusmita Misra
Jul 3, 2021·Journal of Clinical Medicine·Leah PuckettPhilip Mehler
Dec 24, 2021·European Child & Adolescent Psychiatry·E Caitlin LloydRobyn E Wootton

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