Long-term outcomes of anti-VEGF treatment of retinal vein occlusion.

Eye
Kimberly SpoonerAndrew A Chang

Abstract

To analyze the long-term outcomes of eyes with retinal vein occlusion (RVO) 8 years after commencing treatment with anti-vascular endothelial growth factor (VEGF) agents. Retrospective, multicentre study of 221 eyes diagnosed with RVO, which were commenced on anti-VEGF therapy between 2009 and 2011. VA and CRT were recorded at baseline and at subsequent annual time points. The mean number of injections administered each year and the incidence of adverse events were recorded. Of a total of 221 eyes which commenced treatment with anti-VEGF agents for RVO, 95 were diagnosed with BRVO and 126 with CRVO. 8-year data were available for 94 eyes (43%). The mean age of patients was 65.1 ± 12.0 years. Mean VA improved from baseline by 16.9 letters, (57.8-74.7 letters), (P < 0.001). For BRVO eyes, mean VA improved from 60.5 to 74.8 letters (p < 0.001) and for CRVO eyes from 52.0 to 66.4 letters (p < 0.001). In all RVO eyes, there was a reduction in mean CRT from 501.0 to 249.1 µm; in BRVO eyes from 472.4 to 284.7 µm and in CRVO eyes from 533.9 to 267.5 µm. In the 8th year after starting treatment, eyes with RVO were receiving a mean of four injections. Good long-term outcomes of VEGF inhibition for eyes with RVO were found in this study. ...Continue Reading

References

May 1, 2010·Ophthalmology·Rachel L McIntoshTien Yin Wong
Jun 19, 2010·Retina·Ninel Z GregoriPhilip J Rosenfeld
Aug 21, 2010·Ophthalmology·Sohan Singh HayrehM Bridget Zimmerman
Oct 12, 2013·Ophthalmology·Peter A CampochiaroUNKNOWN RETAIN Study Group
Jul 30, 2014·American Journal of Ophthalmology·Yuichiro OguraUNKNOWN GALILEO Study Group
May 10, 2016·Ophthalmology·UNKNOWN Comparison of Age-related Macular Degeneration Treatments Trials (CATT) Research GroupStuart L Fine
Apr 25, 2019·International Journal of Retina and Vitreous·Rahul N KhuranaMark R Wieland
Oct 14, 2019·American Journal of Ophthalmology·Mark GilliesDaniel Barthelmes
Nov 7, 2019·Seminars in Ophthalmology·Sumit Randhir SinghJay Chhablani

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