Long-Term Outcomes of Anticoagulation for Bioprosthetic Valve Thrombosis

Journal of the American College of Cardiology
Ioana PetrescuSorin V Pislaru

Abstract

Early in the prevention and treatment of bioprosthetic valve thrombosis (BPVT), anticoagulation is effective, but the long-term outcome after BPVT is unknown. The goal of this study was to assess the long-term outcomes of patients with BPVT treated with anticoagulation. This analysis was a matched cohort study of patients treated with warfarin for suspected BPVT at the Mayo Clinic between 1999 and 2017. A total of 83 patients treated with warfarin for suspected BPVT (age 57 ± 18 years; 45 men [54%]) were matched to 166 control subjects; matching was performed according to age, sex, year of implantation, and prosthesis type and position. Echocardiography normalized in 62 patients (75%) within 3 months (interquartile range [IQR]: 1.5 to 6 months) of anticoagulation; 21 patients (25%) did not respond to warfarin. Median follow-up after diagnosis was 34 months (IQR: 17 to 54 months). There was no difference in the primary composite endpoint between the patients with BPVT and the matched control subjects (log-rank test, p = 0.79), but the former did have a significantly higher rate of major bleeding (12% vs. 2%; p < 0.0001). BPVT recurred (re-BPVT) in 14 (23%) responders after a median of 23 months (IQR: 11 to 39 months); all but on...Continue Reading

References

Sep 1, 1996·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·J M OliverJ M Mesa
Oct 12, 2002·BMJ : British Medical Journal·David A FitzmauriceGregory Y H Lip
Jul 31, 2013·The American Journal of Cardiology·Adi ButnaruShuli Silberman
May 16, 2014·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Sorin V PislaruHeidi M Connolly
Oct 6, 2015·The New England Journal of Medicine·Raj R MakkarLars Søndergaard
Nov 28, 2015·Journal of the American College of Cardiology·Alexander C EgbeHeidi M Connolly
Nov 5, 2016·Journal of the American College of Cardiology·Nicolaj C HanssonBjarne L Nørgaard
Feb 25, 2017·JACC. Cardiovascular Interventions·Alexander C EgbeSorin V Pislaru
Oct 23, 2017·JACC. Cardiovascular Imaging·Alexander EgbePatricia A Pellikka
Nov 18, 2018·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Robert J LeatherbyWalter Serino
Nov 17, 2019·The New England Journal of Medicine·George D DangasUNKNOWN GALILEO Investigators

❮ Previous
Next ❯

Citations

Oct 29, 2020·Echocardiography·Robin FernandesJayashri Aragam
Jan 12, 2021·Circulation. Cardiovascular Interventions·Toby RogersRon Waksman
Mar 5, 2020·Journal of the American College of Cardiology·Blase A Carabello
Apr 20, 2021·Journal of the American Heart Association·Mohamad AlkhouliRich A Nishimura
Jul 31, 2021·The Thoracic and Cardiovascular Surgeon·Torsten DoenstHristo Kirov
Aug 29, 2021·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Alec VahanianUNKNOWN ESC/EACTS Scientific Document Group
Aug 29, 2021·European Heart Journal·Alec VahanianUNKNOWN ESC Scientific Document Group

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.

Related Papers

European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
Robert J LeatherbyWalter Serino
© 2021 Meta ULC. All rights reserved