Long-term outcomes of children treated with the ketogenic diet in the past

Epilepsia
Amisha PatelEric H Kossoff

Abstract

The ketogenic diet has well-established short- and long-term outcomes for children with intractable epilepsy, but only for those actively receiving it. However, no information exists about its long-term effects years after it has been discontinued. Living subjects were identified who were treated at the Johns Hopkins Hospital with the ketogenic diet from November 1993 to December 2008 for >or=1 month, and had discontinued it >or=6 months prior to this study. Of 530 patients who were eligible, 254 were successfully contacted by phone or e-mail with a survey and request for laboratory studies. Questionnaires were completed by 101 patients, with a median current age of 13 years (range 2-26 years). Median time since discontinuing the ketogenic diet was 6 years (range 0.8-14 years). Few (8%) still preferred to eat high fat foods. In comparison to the 52% responder rate (>50% seizure reduction) at ketogenic diet discontinuation, 79% were now similarly improved (p = 0.0001). Ninety-six percent would recommend the ketogenic diet to others, yet only 54% would have started it before trying anticonvulsants. Lipids were normal (mean total cholesterol 158 mg/dl), despite most being abnormal while on the ketogenic diet. The mean Z scores for...Continue Reading

References

Nov 29, 2002·Developmental Medicine and Child Neurology·Eileen P G ViningJohn M Freeman
May 2, 2003·Nutritional Neuroscience·Carl E Stafstrom, Kristopher J Bough
Aug 21, 2003·JAMA : the Journal of the American Medical Association·Peter O KwiterovichJohn M Freeman
Aug 12, 2006·Journal of Child Neurology·C Beth HendersonDeirdre A Caplin
Nov 18, 2006·Developmental Medicine and Child Neurology·Darcy K GroesbeckEric H Kossoff
Dec 13, 2006·Developmental Medicine and Child Neurology·Patricia Murphy
Jun 15, 2007·Pediatric Neurology·Eric H KossoffGregory K Bergey
Jun 19, 2007·Epilepsy & Behavior : E&B·Adrianna AmariKeith J Slifer
May 6, 2008·Lancet Neurology·Elizabeth G NealJ Helen Cross
May 6, 2008·Lancet Neurology·Max Wiznitzer
Jun 5, 2008·Nature Clinical Practice. Neurology·Alison M Pack
Jul 29, 2008·Journal of Child Neurology·Junaid NizamuddinEric H Kossoff
Aug 23, 2008·Epilepsia·John M FreemanSteven N Goodman
Oct 11, 2008·Brain Research Reviews·Marwan MaaloufMark P Mattson
Dec 17, 2008·Epilepsia·Eric H Kossoff, Jennifer L Dorward

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Citations

May 24, 2012·Current Opinion in Clinical Nutrition and Metabolic Care·Rebecca C Schugar, Peter A Crawford
Mar 5, 2011·Epilepsia·Sharon S McDanielMichael Wong
Apr 8, 2011·Epilepsia·Pierangelo VeggiottiBernardo Dalla Bernardina
Jun 12, 2013·PloS One·David N RuskinSusan A Masino
Jun 4, 2010·Expert Review of Neurotherapeutics·Eric H Kossoff
Feb 10, 2016·Frontiers in Cellular Neuroscience·Jorge Landgrave-GómezRosalinda Guevara-Guzmán
Aug 26, 2014·Epilepsy & Behavior : E&B·Natasha E SchoelerRob Horne
Nov 22, 2011·Neurologia i neurochirurgia polska·Sergiusz JóźwiakKatarzyna Kotulska-Jóźwiak
Mar 22, 2013·Biomedical Journal·Eric H Kossoff, Huei-Shyong Wang
Jul 4, 2012·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Jeong Tae KimHeung Dong Kim
Nov 9, 2011·Seminars in Pediatric Neurology·Sarah A Kelley, Adam L Hartman
Aug 23, 2011·Epilepsy Research·A G Christina Bergqvist
Aug 30, 2011·Epilepsy Research·Tove HallböökBronwen Martin
Mar 29, 2011·Epilepsy & Behavior : E&B·Sudha K KesslerEric H Kossoff
Apr 26, 2011·Epilepsy & Behavior : E&B·Paul R Lee, Eric H Kossoff
Mar 1, 2011·Neuroscience Letters·Sharon S McDaniel, Michael Wong
Nov 9, 2010·Advances in Pediatrics·John M Freeman, Eric H Kossoff
Aug 27, 2015·Medical Hypotheses·Mark F McCartyJames H O'Keefe
May 26, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Andrew P SageYin Tintut
Apr 12, 2016·Seizure : the Journal of the British Epilepsy Association·Fen-Fen NiJia-Lun Wen
Jul 16, 2015·Nutritional Neuroscience·Patricia Azevedo LimaNágila Raquel Teixeira Damasceno
Feb 11, 2015·The International Journal of Biochemistry & Cell Biology·Silvia VidaliRené G Feichtinger
May 23, 2015·The British Journal of Nutrition·W M A D B FernandoR N Martins
Jan 2, 2014·Seizure : the Journal of the British Epilepsy Association·Giangennaro CoppolaAlberto Verrotti
Jul 19, 2011·Seizure : the Journal of the British Epilepsy Association·Roberto CaraballoLuis Paníco
Mar 17, 2015·Frontiers in Cellular Neuroscience·Jorge Landgrave-GómezRosalinda Guevara-Guzmán
Feb 14, 2015·Epilepsy Currents·Eric Kossoff
Dec 3, 2014·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Tove HallböökMaria Dahlin
Jul 30, 2016·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Elles van der LouwJ Helen Cross
Oct 27, 2016·Molecular Genetics and Metabolism·Kathryn M CampPaul M Coates
Feb 12, 2017·Epilepsy & Behavior : E&B·Rima NabboutPeter R Camfield
Apr 26, 2012·Journal of Child Neurology·Wendy Chen, Eric H Kossoff
Dec 1, 2017·Frontiers in Molecular Neuroscience·Marwa ElaminPaola Sacchetti
Jan 1, 2012·Journal of Central Nervous System Disease·James W MitchellAndrea E Cavanna
Feb 28, 2020·Journal of Translational Medicine·Antonio PaoliMassimiliano Caprio
Sep 17, 2020·Nutrients·Francesc Josep García-GarcíaGlòria Garrabou
May 23, 2015·Expert Review of Neurotherapeutics·Steven Parrish WinesettEric H W Kossoff
Aug 12, 2018·Brain Sciences·Tanya J W McDonald, Mackenzie C Cervenka
Jun 18, 2017·SAGE Open Medicine·Nitin AgarwalArie Weinstock
Jan 30, 2020·Nutrients·Jana Ruiz HerreroConsuelo Pedrón Giner
Aug 10, 2020·Anesthesia and Analgesia·Zacherie R ConoverDebnath Chatterjee

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