Long-Term Outcomes of Conversion Hepatectomy for Initially Unresectable Colorectal Liver Metastases

Annals of Surgical Oncology
Yoshiaki MaedaTomonori Hamada

Abstract

Chemotherapy, including molecular targeted agents, for metastatic colorectal cancer has greatly improved recently and offers an increased chance of conversion hepatectomy for patients with initially unresectable liver metastases. However, the long-term outcomes of conversion hepatectomy remain controversial. We retrospectively assessed a consecutive series of 210 patients with colorectal liver metastases to evaluate the long-term outcomes of patients who underwent conversion hepatectomy and to clarify the predictive factors related to the conversion rate. Ninety-four cases were initially resectable and underwent primary hepatectomy. Of the 116 patients with initially unresectable liver metastases, 104 patients underwent chemotherapy (systemic or hepatic artery infusion). Twenty-four percent (11/46) of the initially unresectable liver-limited metastases that became resectable after chemotherapy were subsequently treated with conversion hepatectomy; however, there were no cases of conversion among the patients with extrahepatic metastases. The final resection rate of liver metastases was 50 % (105/210), including conversion hepatectomies. The predicted 5-year survival rate in the conversion hepatectomy group was 76 %. The convers...Continue Reading

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Citations

Mar 8, 2016·Journal of Hepato-biliary-pancreatic Sciences·Seiji OguroSeiji Kawasaki
Mar 27, 2018·The British Journal of Surgery·S YamashitaJ-N Vauthey
Dec 5, 2018·World Journal of Clinical Cases·Feng XuChao-Liu Dai
Mar 3, 2019·Practical Radiation Oncology·Laura A DawsonChristopher G Willett

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