Long-Term Outcomes of Cultivated Limbal Epithelial Transplantation: Evaluation and Comparison of Results in Children and Adults

BioMed Research International
Anita GangerRadhika Tandon

Abstract

To compare the long-term clinical outcomes of cultivated limbal epithelial transplantation (CLET) in children and adults with limbal stem cell deficiency. Retrospective case series. Case records of patients with limbal stem cell deficiency (LSCD) who underwent CLET from April 2004 to December 2014 were studied. Outcome measures were compared in terms of anatomical success and visual improvement. Parameters for total anatomical success were avascular, epithelized, and clinically stable corneal surface without conjunctivalization, whereas partial anatomical success was considered when mild vascularization (sparing centre of cornea) and mild conjunctivalization were noted along with complete epithelization. A total of 62 cases underwent the CLET procedure: 38 (61.3%) were children and 24 (38.7%) were adults. Patients with unilateral LSCD (33 children and 21 adults) had autografts and those with bilateral LSCD (5 children and 3 adults) had allografts. Amongst the 54 autografts partial and total anatomical success were noted in 21.2% and 66.6% children, respectively, and 19.0% and 80.9% in adults, respectively (p value 0.23). Visual improvement of 1 line and ≥2 lines was seen in 57.5% and 21.2% children, respectively, and 38% and 38...Continue Reading

References

Mar 29, 2000·Survey of Ophthalmology·H S Dua, A Azuara-Blanco
Jul 13, 2000·The New England Journal of Medicine·R J TsaiJ K Chen
Apr 27, 2004·Experimental Eye Research·Robert M LavkerTung-Tien Sun
Mar 16, 2005·Archives of Ophthalmology·Virender S SangwanGullapalli N Rao
Jun 25, 2010·The New England Journal of Medicine·Paolo RamaGraziella Pellegrini
Sep 6, 2011·The British Journal of Ophthalmology·Virender S SangwanDorairajan Balasubramanian
Apr 6, 2013·JAMA Ophthalmology·Kunjal SejpalVirender S Sangwan

❮ Previous
Next ❯

Citations

Apr 24, 2020·JAMA Ophthalmology·Qihua LeSophie X Deng
Jul 13, 2017·Scientific Reports·Naresh PolisettiUrsula Schlötzer-Schrehardt
Dec 6, 2019·Stem Cells Translational Medicine·Catherine J JacksonTor P Utheim
Jul 10, 2019·Current Eye Research·Sachin ShuklaSayan Basu
Jul 6, 2019·Current Ophthalmology Reports·Ghasem YazdanpanahAli R Djalilian
Mar 11, 2021·The British Journal of Ophthalmology·Praveen ThokalaVirender Singh Sangwan
Jun 15, 2021·Frontiers in Medicine·Aastha Singh, Virender S Sangwan
Aug 27, 2021·Bioengineering·Mohamed Abdul-AlFarshid Sefat

❮ Previous
Next ❯

Methods Mentioned

BETA
dissection

Software Mentioned

StataCorp LP
Excel Spreadsheet

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.