Long-term outcomes of endoscopic submucosal dissection for high-grade dysplasia and early-stage carcinoma in the colorectum

Cancer Communications
Tao ChenPinghong Zhou

Abstract

Colorectal carcinomas (CRCs) arise from premalignant precursors in an adenoma-carcinoma sequence, in which adenoma with high-grade dysplasia (HGD) and early-stage carcinoma are defined as advanced neoplasia. A limited number of studies have evaluated the long-term outcomes of endoscopic submucosal dissection (ESD) for advanced colorectal neoplasia. This study aimed to assess the efficacy and safety of ESD for advanced colorectal neoplasia as well as the long-term outcomes, including local recurrence and metastasis. We analyzed data collected from 610 consecutive patients with 616 advanced colorectal neoplasia lesions treated with ESD between January 2007 and December 2013. Clinical, endoscopic, and histological data were collected over a median follow-up period of 58 months to determine tumor stage and type, resection status, complications, tumor recurrence, and distant metastasis. The overall rates of en bloc resection, histological complete resection, and major complications were 94.3%, 89.4%, and 2.3%, respectively. Hybrid ESD was an independent factor of piecemeal resection. Tumor location in the colon was associated with increased risk of ESD-related complications. During the follow-up period, all patients remained free of...Continue Reading

References

May 1, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Mitsuhiro FujishiroMasao Omata
Mar 22, 2008·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·D P HurlstoneS S Cross
Jul 21, 2009·Diseases of the Colon and Rectum·Alessandro RepiciAlberto Malesci
May 1, 2010·Lancet·Wendy S AtkinUNKNOWN UK Flexible Sigmoidoscopy Trial Investigators
Dec 7, 2011·Journal of Gastroenterology and Hepatology·Koichi NakadoiKazuaki Chayama
May 28, 2013·Gut and Liver·Yutaka SaitoTakahisa Matsuda
Aug 22, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Shinji YoshiiMasao Hosokawa
Apr 1, 2014·Gastrointestinal Endoscopy Clinics of North America·Takashi ToyonagaTakeshi Azuma
Jan 7, 2015·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Jan 27, 2015·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·M S SawhneyE Yee
Feb 6, 2015·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Shinji TanakaHisao Tajiri
Mar 19, 2015·International Journal of Clinical Oncology·Toshiaki WatanabeUNKNOWN Japanese Society for Cancer of the Colon and Rectum
Apr 8, 2015·The American Journal of Gastroenterology·Shiro OkaUNKNOWN Colorectal Endoscopic Resection Standardization Implementation Working Group of the Japanese Society for Cancer of the Colon
Aug 11, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Tao ChenYun-Shi Zhong
Jan 1, 2016·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Michael J BartelMichael B Wallace
Aug 1, 2016·Gastrointestinal Endoscopy·Kenjiro ShigitaKazuaki Chayama
Aug 4, 2016·Chinese Journal of Cancer·Wanqing ChenSiwei Zhang
Sep 2, 2016·Journal of the National Cancer Institute·Thomas F ImperialeDavid F Ransohoff

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Citations

Sep 4, 2019·International Journal of Colorectal Disease·Shinichiro MakimotoYoshiharu Shono
Sep 4, 2020·World Journal of Gastrointestinal Oncology·Sakti ChakrabartiAmit Mahipal
Jan 24, 2020·GE Portuguese Journal of Gastroenterology·Miguel Araújo-MartinsMário Dinis-Ribeiro

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Methods Mentioned

BETA
dissection
surgical resection

Software Mentioned

SPSS Statistics

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