Long-term outcomes of epilepsy surgery in tuberous sclerosis complex

Journal of Neurology
Shuli LiangPing Ding

Abstract

Approximately 50% of patients with tuberous sclerosis complex (TSC) present intractable epilepsy, and surgery is an option for those patients. Hereby, we analyze long-term seizure control and neuropsychological outcomes of epilepsy surgery in patients with TSC. Clinical data were retrospectively collected from 66 patients with TSC and epilepsy followed up over 5 years, 51 of whom underwent epilepsy surgery between 2001 and 2011. Reductions in the number of seizures were analyzed at 1-year (1FU), 5-year (5FU), and 10-year (10FU) follow-ups visits after the operation. Influential factors on postoperative seizure free and intelligence quotient (IQ) and quality-of-life (QOL) outcomes were evaluated at 5FU. Resective procedures included 26 tuber resections, 15 lobectomies, and 10 tuber resections and lobectomies. Corpus callosotomies were performed as the adjunctive approach in 11 cases with low IQ. The percentages of seizure-free cases were 74.5% at 1FU, 58.8% at 5FU, and 47.8% at 10FU, and the predictive factor for long-term postoperative seizure freedom was the history of preoperative seizures and preoperative full-scale IQ. Significant improvements were found in performance IQ, full-scale IQ, and QOL in patients from the surgery...Continue Reading

References

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Citations

Sep 20, 2018·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Derek S LuHoward L Weiner
Jan 18, 2018·Expert Review of Neurotherapeutics·Paolo CuratoloEleonora Aronica
Mar 15, 2019·Epilepsia Open·Rima NabboutUNKNOWN TOSCA Consortium and TOSCA Investigators
Sep 22, 2020·Journal of Neuropathology and Experimental Neurology·Angelika MühlebnerEleonora Aronica
Jun 19, 2019·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Michael A StellonChima O Oluigbo
Aug 24, 2020·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Shimrit Uliel-SibonyAviva Fattal-Valevski
Jan 8, 2021·Annals of Neurology·Alexander L CohenUNKNOWN Tuberous Sclerosis Complex Autism Center of Excellence Network Study Group
Aug 6, 2021·Therapeutic Advances in Neurological Disorders·Susanne Schubert-Bast, Adam Strzelczyk
Aug 30, 2021·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·H AlexanderC O Oluigbo
Sep 16, 2021·PharmacoEconomics Open·Siu Hing LoAndrew Lloyd

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