Long-term outcomes of galantamine treatment in patients with Alzheimer disease

The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry
Constantine G LyketsosYoung Zhu

Abstract

The authors evaluated the long-term safety, efficacy, and tolerability of galantamine 24 mg/day in the treatment of Alzheimer disease by means of a 12-month, open-label extension of an earlier 5-month, double-blind, placebo-controlled trial with a 6-week withdrawal phase. Patients completing two double-blind, placebo-controlled trials (N=699) were escalated to a 24-mg dose (12 mg bid) of galantamine during a period of 2 weeks and treated for 12 months beyond the initial 6.5-month, double-blind period (total treatment duration: 18.5 months). The primary efficacy measure was the change from baseline in the Alzheimer's Disease Assessment Scale (ADAS-Cog/11) score at 18.5 months; secondary endpoints included total scores on the Alzheimer's Disease Cooperative Study of Activities of Daily Living and the Neuropsychiatric Inventory. Standard safety evaluations, including adverse-event monitoring, were performed. Patients taking galantamine continuously throughout the double-blind and open-label studies (N=288) showed sustained cognitive benefits on ADAS-Cog/11 scores at 18.5 months. Patients were maintained close to baseline cognitive ability for 12 months, and safety was as expected and documented in other large studies of galantamin...Continue Reading

Citations

Jul 4, 2007·Primary Care Companion to the Journal of Clinical Psychiatry·David S Geldmacher
Nov 30, 2007·Clinical Interventions in Aging·Shailaja Shah, William E Reichman
Jul 14, 2009·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Kaori ItoUNKNOWN Alzheimer's Disease Working Group
Nov 3, 2010·Journal of Evaluation in Clinical Practice·Bowers MeganMark Weatherall

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