Long-term outcomes of gastric mucosa-associated lymphoid tissue lymphomas after Helicobacter pylori eradication therapy

The Tohoku Journal of Experimental Medicine
Shiho TeraiTooru Shimosegawa

Abstract

Mucosa-associated lymphoid tissue (MALT) lymphomas are localized primarily in the gastrointestinal tract and are characterized by an indolent nature and favorable outcome with specific therapy. Gastric MALT lymphomas are closely linked to Helicobacter pylori (H. pylori) infection, for which eradication therapy is recognized as an effective primary treatment for the disease. However, there is little information about long-term outcomes after the therapy. In the present study, we elucidated the long-term outcomes of 74 patients (70 H. pylori-positive and 4 negative cases) followed up by endoscopy at least 12 months after exclusive eradication therapy alone. The median follow-up period was 46 months. When the remission status was estimated at the time point of 12 months post-eradication, the numbers of patients with complete remission (CR), histologically residual disease with macroscopic normalization (hRD), partial remission with more than 50% tumor reduction (PR) or no response (NR) were 56, 12, 2 and 4, respectively. During follow-ups of over 12 months post-eradication, 11 of the 12 hRD cases were belatedly induced to CR but one CR case histologically relapsed into hRD. One of the 2 PR cases eventually turned into hRD 20 month...Continue Reading

Associated Clinical Trials

Apr 24, 2012·Werner Dolak, MD

References

Feb 28, 2002·The American Journal of Gastroenterology·Michaël LevyUNKNOWN Groupe d'Etude des Lymphomes de l'Adulte (GELA)
Apr 16, 2002·Gut·M StolteA Neubauer
Sep 21, 2002·Lancet·Wolfgang FischbachHans Konrad Müller-Hermelink
Dec 14, 2002·Blood·Mustafa BenekliMeir Wetzler
Nov 14, 2003·Journal of Gastroenterology·Tsuneya NakamuraShigeo Nakamura
Jan 13, 2004·World Journal of Gastroenterology : WJG·Sang Kil LeeWoo Ik Yang
Mar 3, 2005·Virchows Archiv : an International Journal of Pathology·Antoine de MascarelJean-Philippe Merlio
Oct 6, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas WündischAndreas Neubauer

❮ Previous
Next ❯

Citations

Jan 25, 1997·Lancet·C S GoodwinT C Northfield
Apr 11, 2007·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Kenichi Sawada, Naoto Takahashi
May 5, 2010·World Journal of Gastroenterology : WJG·Hyung Soon ParkYong Chan Lee
Jul 28, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Angelo ZulloDino Vaira
Oct 24, 2008·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·A AndrianiA Zullo
Apr 22, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Hideomi YamashitaKuni Ohtomo
Sep 12, 2008·Helicobacter·António Carlos FerreiraYoshio Yamaoka
Sep 17, 2011·Alimentary Pharmacology & Therapeutics·J P Gisbert, X Calvet
Jun 18, 2009·The American Journal of Gastroenterology·Angelo ZulloDino Vaira
Jul 1, 2010·Expert Opinion on Pharmacotherapy·Anastasios StathisEmanuele Zucca
Jul 18, 2015·World Journal of Gastroenterology : WJG·Naoki AsanoTooru Shimosegawa
Dec 25, 2019·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Eun Jeong Gong, Kee Don Choi
Aug 30, 2008·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Kensei TobinaiMorihito Takita

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.