Long term outcomes of intestinal rehabilitation in children with neonatal very short bowel syndrome: Parenteral nutrition or intestinal transplantation

Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
Lorenzo NorsaOlivier Goulet

Abstract

Intestinal rehabilitation is the preferred treatment for children with short bowel syndrome (SBS) whatever the residual bowel length, and depends on the accurate management of long-term parenteral nutrition (PN). If nutritional failure develops, intestinal transplantation (ITx) should be discussed and may be life-saving. This study aimed to evaluate survival, PN dependency and nutritional status in children with neonatal very SBS on PN or after ITx, in order to define indications and timing of both treatments. This retrospective cross-sectional study enrolled 36 children with very SBS (<40 cm) who entered our intestinal rehabilitation program from 1987 to 2007. All the children on long-term PN (n = 16) survived with a follow-up of 17 years (9-20). Six of them were eventually weaned off PN. Twenty children underwent ITx: eight children died (40%) 29 months (0-127) after Tx. The others 12 patients were weaned off PN 73 days (13-330) after Tx. Follow-up after transplantation was 14 years (6-28). Seven out of 8 (88%) patients with a history of gastroschisis required ITx. Patients who required ITx had longer stoma duration. Survival rate of children with very short bowel was excellent if no life-threatening complications requiring t...Continue Reading

Citations

Jun 7, 2019·Journal of Pediatric Gastroenterology and Nutrition·Sz-Ying C JoJulie E Bines
Apr 12, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Sophie CourbageFlorence Lacaille
Feb 1, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Racha T Khalaf, Ronald J Sokol
Oct 30, 2018·World Journal of Transplantation·Ignazio R Marino, Augusto Lauro
Jul 25, 2019·Pediatric Gastroenterology, Hepatology & Nutrition·Olivier GouletCécile Lambe
Feb 23, 2019·Expert Review of Gastroenterology & Hepatology·Augusto Lauro, Florence Lacaille
Oct 24, 2020·Journal of Pediatric Gastroenterology and Nutrition·Abdalla Kara BallaStuart S Kaufman
Nov 17, 2020·Journal of Paediatrics and Child Health·Jason Y K YapJulie E Bines
Apr 30, 2020·Journal of Pediatric Surgery·Rashikh A ChoudhuryRaphael N Vuille-Dit-Bille
Sep 27, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Elie Abi NaderOlivier Goulet
Apr 22, 2021·JPEN. Journal of Parenteral and Enteral Nutrition·Roxana FatemizadehMuralidhar H Premkumar
Aug 7, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Francesco ProliCécile Lambe

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