Long-term outcomes of persistent disease and relapse in primary membranous nephropathy

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Durga A K KanigicherlaMichael C Venning

Abstract

Primary membranous nephropathy is associated with variable clinical course ranging from spontaneous remission to slow progression to end stage renal failure. Achieving remission confers better renal survival in primary membranous nephropathy (PMN). Longer term outcomes such as patient survival and relapse of active disease remain poorly understood. We performed a retrospective study of 128 consecutive adult patients diagnosed with biopsy proven PMN at a single UK centre between 1980 and 2010. These patients were followed prospectively over a median of 128 months. We assessed impact of persistent disease and relapse on Stage 5 chronic kidney disease (CKD-5) and patient survival and present longer term cumulative incidences of different end points. One hundred patients achieved partial remission (PartRem) and 28 patients did not achieve remission (NoRem). Nine per cent of patients achieving first remission developed CKD-5 and 75% of those with NoRem developed CKD-5 [hazard ratio (HR) 0.07, 95% confidence interval 0.03-0.19). Relapse following PartRem occurred in 31 patients (31%) during follow-up and was significantly associated with progression to CKD-5. Progression to CKD-5 was strongly associated with death (47 versus 6%, HR 2...Continue Reading

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Citations

Nov 1, 2016·Journal of the American Society of Nephrology : JASN·An S De VrieseFernando C Fervenza
Jan 10, 2017·Kidney International·Daniel C Cattran, Paul E Brenchley
Apr 10, 2017·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Daniel Cattran, Paul Brenchley
Mar 8, 2018·BioMed Research International·Agnieszka PozdzikKarl Martin Wissing
Dec 11, 2019·International Urology and Nephrology·Huaiya XieXuewang Li
Jun 27, 2018·Clinical Kidney Journal·Soumita BagchiSanjay Kumar Agarwal
Jul 27, 2017·Terapevticheskiĭ arkhiv·V A DobronravovA V Smirnov
Apr 5, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Patrick HamiltonDavid Meads
Feb 23, 2020·Clinical Kidney Journal·Patrick HamiltonPaul Brenchley
Mar 25, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Claudio PonticelliFrancesco Locatelli
Jun 11, 2020·KI Reports·Elisa DelbarbaUNKNOWN CureGN Consortium

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