Long-term outcomes of stimulant medication in attention-deficit hyperactivity disorder

Expert Review of Neurotherapeutics
Alison Poulton

Abstract

The rate of prescribing of stimulant medication for the treatment of attention-deficit hyperactivity disorder (ADHD) has been progressively increasing in countries such as the USA and Australia. In the short term, stimulant medication is effective in reducing the symptoms of ADHD and appears well tolerated with relatively minor side effects. In the long term, much of the benefit of stimulant medication disappears after medication is ceased. Studies have demonstrated only marginal improvements in adult outcomes following a period of treatment in childhood. This may be owing to the beneficial effects being masked by the variability of the condition, the developmental changes in symptomatology that happen with maturation and the substantial influence of social and environmental factors. Stimulant medication may give some protection against later substance abuse. Stimulant medication may slightly elevate the blood pressure and possibly increase susceptibility to seizures and to tics and Tourette syndrome. Starting treatment with stimulant medication is usually associated with weight loss and a transient slowing of the height velocity, although it is believed that most children catch up during puberty. No studies were found that lis...Continue Reading

References

Mar 1, 1975·The American Journal of Psychiatry·P O Quinn, J L Rapoport
Jan 1, 1975·The Journal of Pediatrics·D J SaferE Barr
Mar 1, 1992·Journal of the American Academy of Child and Adolescent Psychiatry·T SpencerM Danon
Jan 1, 1992·Diseases of the Colon and Rectum·J S Thompson, S M Williams
Mar 1, 1985·Journal of the American Academy of Child Psychiatry·G WeissT Perlman
Jun 1, 1985·Annals of Emergency Medicine·O StecykJ Jacobs
Aug 3, 1972·The New England Journal of Medicine·D SaferE Barr
Apr 1, 1984·Journal of Clinical Gastroenterology·H MehtaT A LoIudice
Sep 1, 1980·Journal of Developmental and Behavioral Pediatrics : JDBP·J H SatterfieldS D Barb
Mar 1, 1983·Archives of General Psychiatry·J A Mattes, R Gittelman
Mar 26, 1982·JAMA : the Journal of the American Medical Association·T L LoweB A Shaywitz
Oct 1, 1982·Developmental Medicine and Child Neurology·J E KalachnikR K Ullmann
Jan 1, 1981·Journal of the American Academy of Child Psychiatry·L L GreenhillE J Sachar
Mar 1, 1993·Journal of the American Academy of Child and Adolescent Psychiatry·M FischerL Smallish
Nov 1, 1996·Journal of the American Academy of Child and Adolescent Psychiatry·T J SpencerT E Wilens
Sep 18, 1997·Journal of the American Academy of Child and Adolescent Psychiatry·S MannuzzaM E Hynes
Oct 23, 1997·Journal of the American Academy of Child and Adolescent Psychiatry·L M MustenJ Mercer
Apr 1, 1997·The Journal of Pediatrics·V Gross-TsurR S Shalev
Apr 18, 1998·The American Journal of Psychiatry·S MannuzzaM LaPadula
May 29, 1998·The Journal of Pediatrics·P J Marotta, E A Roberts
Jan 23, 1999·Psychiatry and Clinical Neurosciences·W W Yan
Oct 16, 1999·Journal of Child and Adolescent Psychopharmacology·C E PaterniteM A Whaley
Mar 4, 2000·JAMA : the Journal of the American Medical Association·J M ZitoF Lynch
Mar 29, 2001·Pediatric Neurology·S A HemmerB L Trommer
Aug 15, 2001·Journal of the American Academy of Child and Adolescent Psychiatry·D ThiruchelvamR J Schachar
Mar 1, 2002·Nordic Journal of Psychiatry·Anne Mari Sund, Pål Zeiner
Aug 8, 2002·Journal of the International Neuropsychological Society : JINS·Russell A BarkleyTracie Bush
Dec 12, 2002·Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie·J K SchmidtA von Gontard
Feb 22, 2003·Journal of the American Academy of Child and Adolescent Psychiatry·Wendy Klein-Schwartz, Jean McGrath
Mar 26, 2003·Journal of Paediatrics and Child Health·A Poulton, C T Cowell
Jun 5, 2003·The American Journal of Psychiatry·Mark OlfsonPeter S Jensen
Jul 26, 2003·Journal of Pediatric Endocrinology & Metabolism : JPEM·Megan C Lisska, Scott A Rivkees
Jul 30, 2003·Archives of General Psychiatry·T SpencerS Faraone
Dec 3, 2003·Brain : a Journal of Neurology·Anna MoszczynskaStephen J Kish
Feb 26, 2004·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Russell A BarkleyKenneth Fletcher
Apr 22, 2004·Journal of the American Academy of Child and Adolescent Psychiatry·Alice CharachRussell Schachar
Jul 2, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Paul M ThompsonEdythe D London

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Citations

Dec 2, 2006·Neurotoxicology and Teratology·Hsiang-Shu Yin, Hsu-Wen Tan
Jul 1, 2012·Evidence-based Child Health : a Cochrane Review Journal·Michael H Bloch
Dec 7, 2018·Expert Review of Neurotherapeutics·Isabella BerardelliGiovanni Fabbrini
Mar 11, 2017·The South African Journal of Communication Disorders. Die Suid-Afrikaanse Tydskrif Vir Kommunikasieafwykings·Tessa L RauschAnita Van der Merwe

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