Long-term outcomes of surgical intervention in patients with end-stage hepatic alveolar echinococcosis

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
Lei LiYonggang Wei

Abstract

To investigate the clinical effects of surgical intervention for end-stage hepatic alveolar echinococcosis (HAE). We conducted a retrospectively study included 561 end-stage HAE patients between 2004 and 2016. The demographic characteristics, clinical data, and follow-up outcomes were collected and analysed. Kaplan-Meier curves were used for the overall survival (OS) and disease progression-free survival (PFS) analyses. COX multivariable regression analysis was carried out to identify risk factors. A total of 122 patients received surgical intervention were included, 55 cases underwent two-stage hepatectomy (group A, n=55), 21 cases underwent liver transplantation (group B, n=21), and 46 cases underwent non-radical reduction hepatectomy (groupC, n=46). The perioperative morbidity and mortality of liver transplantation group were significantly higher than other groups (47.6% and 14.3%). In group A, the 5- and 10-year OS rates were both 94.12%, and the 5- and 10-year PFS rates were both 91.18%. In group B, the 5- and 10-year OS rates were both 94.44%, and the 5- and 10-year PFS rates were both 94.44%. In group C, the 5- and 10-year OS rates were both 74.05%, and the 5- and 10-year PFS rates were both 54.58%. The rate of favorable...Continue Reading

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