Long-Term Outcomes of the Mosaic Bioprosthesis

The Annals of Thoracic Surgery
Friedrich-Christian RiessM E Legget

Abstract

The Mosaic bioprosthesis is a third-generation stented porcine bioprosthesis. This study was performed to evaluate long-term survival and durability associated with this device. A total of 1,029 patients (797 aortic valve replacements, 232 mitral valve replacements) previously enrolled at 6 centers as part of the original regulatory study were included. We evaluated freedom from death, valve-related reoperation, and explant due to structural valve deterioration (SVD), and compared these outcomes by age (<60 and ≥60 years) at the time of implant. Cumulative follow-up was 7021.2 patient-years in the aortic cohort and 1969.5 patient-years in the mitral cohort. Mean age was 69.5 ± 8.6 and 67.9 ± 10.5 years; 66% and 48% were male, respectively. In the aortic cohort at 17 years, freedom from death was 54.0% in patients younger than 60 years and 24.0% in patients aged 60 years and older (p < 0.01); freedom from reoperation was 36.4% and 81.2%, respectively (p < 0.01); and freedom from explant due to SVD was 47.5% and 89.1% (p < 0.01). At 16 years in the mitral cohort, freedom from death was 67.6% and 20.6% (p < 0.01); freedom from reoperation was 51.3% versus 77.9% (p = 0.04); and freedom from explant due to SVD was 65.2% versus 83.8%...Continue Reading

Citations

Jun 20, 2020·Circulation Journal : Official Journal of the Japanese Circulation Society·Yasushi YoshikawaYoshiki Sawa
Feb 12, 2021·Interactive Cardiovascular and Thoracic Surgery·Stephen D ThorpTomasz A Timek
Mar 12, 2021·Interactive Cardiovascular and Thoracic Surgery·Giovanni A ChiarielloIssam Abouliatim
May 24, 2021·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Kazuyoshi TakagiEiki Tayama
Sep 17, 2021·Circulation Journal : Official Journal of the Japanese Circulation Society·Yasushi YoshikawaYoshiki Sawa
Nov 28, 2021·Journal of Medical Ultrasonics·Ritsuko KurimotoHiroki Mani

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