Long-term outcomes of upfront surgery in patients with resectable pathological N2 non-small-cell lung cancer.

European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
Jae Kwang YunSehoon Choi

Abstract

Although the standard treatment for pathological N2 (pN2) non-small-cell lung cancer (NSCLC) patients is definitive chemoradiation, surgery can be beneficial for resectable pN2 disease. Herein, we report the long-term clinical outcomes of upfront surgery followed by adjuvant treatment for selected patients with resectable pN2 disease. We performed a retrospective analysis of clinical outcomes for patients with pN2 disease who underwent surgery as the first-line therapy. Multivariable Cox regression analysis was used to identify the significant factors for overall survival (OS) and recurrence-free survival. From 2004 to 2015, a total of 706 patients with pN2 NSCLC underwent complete anatomical resection at our institution. The patients' clinical N stages were cN0, 308 (43.6%); cN1, 123 (17.4%) and cN2, 275 (39.0%). Adjuvant chemotherapy, radiotherapy and chemoradiotherapy were administered to 169 (23.9%), 115 (17.4%) and 299 patients (42.4%), respectively. With a median follow-up of 40 months, the respective median time and 5-year rate of OS were 52 months and 44.7%. According to subdivided pN2 descriptors, the median OS time was 80, 53 and 37 months for patients with pN2a1, pN2a2 and pN2b, respectively. Adjuvant chemotherapy wa...Continue Reading

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Citations

Nov 17, 2020·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jae Kwang YunYoung Mog Shim
Feb 20, 2021·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Jae Kwang YunHyeong Ryul Kim
Mar 26, 2021·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jae Kwang YunDong Kwan Kim
May 18, 2021·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Julian M M RogaschChristian Furth
Feb 17, 2021·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Ho Cheol KimUNKNOWN Korea Central Cancer Registry
Mar 31, 2021·The Annals of Thoracic Surgery·Tianxiang ChenQingquan Luo

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