Long-Term Pain Treatment Did Not Improve Sleep in Nursing Home Patients with Comorbid Dementia and Depression: A 13-Week Randomized Placebo-Controlled Trial

Frontiers in Psychology
Kjersti Marie BlyttBjørn Bjorvatn

Abstract

Objective: Previous research indicates that pain treatment may improve sleep among nursing home patients. We aimed to investigate the long-term effect of pain treatment on 24-h sleep patterns in patients with comorbid depression and dementia.Design:A 13-week, multicenter, parallel-group, double-blind, placebo-controlled randomized clinical trial conducted between August 2014 and September 2016.Setting:Long-term patients from 47 nursing homes in Norway.Participants:We included 106 patients with comorbid dementia and depression according to theMini Mental Status Examination (MMSE)and theCornell Scale for Depression in Dementia (CSDD).Intervention:Patients who were not using analgesics were randomized to receive either paracetamol (3 g/day) or placebo tablets. Those who already received pain treatment were randomized to buprenorphine transdermal system (maximum 10 μg/h/7 days) or placebo transdermal patches.Measurements:Sleep was assessed continuously for 7 days by actigraphy, at baseline and in week 13. Total sleep time (TST), sleep efficiency (SE), sleep onset latency (SOL), wake after sleep onset (WASO), early morning awakening (EMA), and number of wake bouts (NoW) were evaluated. In addition, daytime total sleep time (DTS) was...Continue Reading

Associated Clinical Trials

References

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Citations

May 1, 2019·Expert Opinion on Drug Safety·Ane ErdalBettina Sandgathe Husebo
Aug 4, 2020·International Psychogeriatrics·Kjersti Marie Blytt, Elisabeth Flo-Groeneboom
Nov 15, 2020·The Cochrane Database of Systematic Reviews·Jenny McCleery, Ann L Sharpley
May 28, 2021·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Wan-Tai M Au-YeungIpsit V Vahia
Aug 30, 2021·The International Journal of Pharmacy Practice·Sarah BloukhCatriona Matheson

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Methods Mentioned

BETA
sedation

Clinical Trials Mentioned

NCT02267057

Software Mentioned

SPSS Statistics
Actiware

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