Long-term persistence after acute Q fever of non-infective Coxiella burnetii cell components, including antigens

QJM : Monthly Journal of the Association of Physicians
O SukochevaStephen R Graves

Abstract

Previous studies of inciting factors for a prolonged post-infection fatigue syndrome after Q fever (variously termed QFS or Q fever associated CFS/ME in the literature) showed that after the acute infection a high proportion of asymptomatic and QFS patients had Q fever antibody and also low levels in PBMC and bone marrow of Coxiella burnetii (C.b.) DNA with PCR assays directed against three different target sequences in different parts of the coxiella genome. Attempts to isolate a strain of C.b. in A/J mice, and cell culture from PCR positive PBMC and bone marrow were consistently negative. The detailed composition of the persisting coxiella residues remains to be defined. To retest and provide detailed results on selected PCR positive samples from the Birmingham Q fever outbreak patients tested by a highly sensitive method to detect viable organisms and to determine the nature of the residual coxiella cell components. Laboratory case study. NOD/SCID mice were inoculated with samples from the 1989 Q fever outbreak in Birmingham and followed for evidence of infection and the presence of coxiella DNA and specific antigens in spleen and liver macrophages. A significant, unexpected finding of specific antigen was followed by assess...Continue Reading

References

May 18, 1989·Nature·S Kwok, R Higuchi
Feb 10, 1983·Nature·G C BosmaM J Bosma
Apr 6, 1996·Lancet·B P MarmionI Penttila
Oct 1, 1996·Annals of Hematology·S Baatout
Nov 14, 1997·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·T LapidotO Kollet
May 14, 1998·QJM : Monthly Journal of the Association of Physicians·J G AyresB P Marmion
Jan 20, 1999·QJM : Monthly Journal of the Association of Physicians·I A PenttilaB P Marmion
Sep 12, 2000·Epidemiology and Infection·R J HarrisB P Marmion
May 11, 2001·Annals of Internal Medicine·S Wessely
Jul 30, 2002·QJM : Monthly Journal of the Association of Physicians·M J WildmanJ G Ayres
Jan 1, 1958·Japanese Journal of Microbiology·W YONEZAWAA TANABE
Mar 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Amélie HonstettreJean-Louis Mege
Dec 31, 2004·QJM : Monthly Journal of the Association of Physicians·B P MarmionR J Harris
Jun 16, 2005·QJM : Monthly Journal of the Association of Physicians·K HelbigB P Marmion
Dec 14, 2005·Current Opinion in Immunology·Kim Theilgaard-MönchNiels Borregaard
Feb 17, 2006·Annals of the New York Academy of Sciences·Jan Kazar
Jul 25, 2006·International Review of Cytology·Georg Kraal, Reina Mebius
Nov 23, 2006·Annals of the New York Academy of Sciences·M TurraM Qiao
Dec 4, 2009·Journal of Clinical Pathology·Lihan ZhangJonathan R Kerr

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Citations

Apr 5, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Brendan HealyMeirion Llewelyn
Jul 10, 2012·QJM : Monthly Journal of the Association of Physicians·H Hussain-YusufS Graves
Nov 30, 2012·Clinical and Vaccine Immunology : CVI·Gilbert J KershRobert F Massung
Dec 17, 2011·Emerging Infectious Diseases·Jolianne M RijksAndrea Gröne
Jan 29, 2016·The Journal of Infection·Stephan P KeijmelMarcel van Deuren
Jun 18, 2011·Comparative Immunology, Microbiology and Infectious Diseases·Ashraf AlsalehFrancis Fieni
Oct 29, 2015·Epidemiology and Infection·G J M LimonardM H Nabuurs-Franssen
Nov 5, 2016·QJM : Monthly Journal of the Association of Physicians·Beth HopperAndrew R Lloyd
Nov 19, 2011·FEMS Immunology and Medical Microbiology·Michelle LockhartJohn Stenos
Apr 20, 2016·BMC Infectious Diseases·Olga A SukochevaBarrie P Marmion
Sep 4, 2014·Asian Pacific Journal of Tropical Biomedicine·Mohammad KhaliliHossein Norouzian Mirza
May 26, 2016·PloS One·Gabriella MorroyChantal P Bleeker-Rovers
Nov 20, 2016·Clinical Microbiology Reviews·Carole EldinDidier Raoult
Sep 17, 2015·Circulation·Robert S BaltimoreUNKNOWN American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee of the Council on Cardiovascular Di
Aug 1, 2019·Open Forum Infectious Diseases·Ruud Ph RaijmakersStephen R Graves
Dec 16, 2018·Vaccines·Emily SellensNicholas Wood
Jul 10, 2021·Transboundary and Emerging Diseases·Juliane AnkertMathias W Pletz

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