Long-term persistence of anti-rods and rings antibodies in patients with chronic hepatitis C after antiviral treatment

Immunologic Research
Ana Beatriz da Silva SacerdoteEdmundo Pessoa Lopes

Abstract

Anti-rods and rings (anti-RR) antibodies are related to hepatitis C virus (HCV) in patients treated with pegylated interferon (PEG-IFN) and ribavirin (RBV). Only RBV induces rods/rings structures in vitro; but in vivo, the antibody appearance is related to the combination of these drugs, because data about patients using just one of these drugs alone is missing. Some studies suggest disappearance of these antibodies over time. The aim of this study was to describe the occurrence of anti-RR in patients with chronic hepatitis C treatment-naïve or previously PEG-IFN/RBV-experienced, evaluating the persistence of anti-RR antibodies long after PEG-IFN/RBV treatment. From 2016 to 2017, 70 HCV-infected patients were screened for anti-RR using indirect immunofluorescence. Demographic and clinical data about previous treatments against HCV were assessed. Thirty-four patients (49%) had been previously treated with PEG-IFN/RBV and the average time since they had received the last antiviral treatment was 85.4 months. Anti-RR seropositivity was detected in 16 patients (23%), and all of these had used PEG-IFN/RBV (corresponding to 47% of experienced patients). Previous antiviral treatment and previous exposure time to RBV were associated wit...Continue Reading

References

Sep 1, 1995·Revista Do Instituto De Medicina Tropical De São Paulo·E P LopesM L Ferraz
Oct 19, 2001·Journal of Clinical Gastroenterology·Y C PengG H Chen
Sep 13, 2003·Journal of Virology·Laurence CocquerelShoshana Levy
Mar 24, 2009·Journal of Viral Hepatitis·M J WilliamsUNKNOWN Trent HCV Group
Apr 6, 2013·BMC Medicine·Zahava VadaszElias Toubi
Jul 22, 2014·Journal of Viral Hepatitis·Cristina NovembrinoMassimo Colombo
Dec 3, 2014·Journal of Hepatology·Rachel H Westbrook, Geoffrey Dusheiko
Feb 16, 2016·World Journal of Gastroenterology : WJG·Gerson Dierley KeppekeLuis Eduardo C Andrade
Aug 18, 2017·Medical Microbiology and Immunology·Werner DammermannStefan Lüth

❮ Previous
Next ❯

Citations

Jun 17, 2020·Immunologic Research·Ana Beatriz da Silva SacerdoteEdmundo Pessoa Lopes
Feb 5, 2021·Microbiology and Immunology·Bilal Olcay PekerElif Sarıtaş Yüksel
Aug 18, 2020·Autoimmunity Reviews·S John Calise, Edward K L Chan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.