Long-term persistence of both functional and non-functional alleles at the leukocyte immunoglobulin-like receptor A3 (LILRA3) locus suggests balancing selection

Human Genetics
Kouyuki HirayasuToshio Yabe

Abstract

The leukocyte immunoglobulin-like receptor (LILR) family consists of 13 loci, and a number of variations have been identified in these genes. Some polymorphisms of the LILR genes are reported to be associated with susceptibility to diseases such as rheumatoid arthritis and multiple sclerosis. LILRA3, one of the LILR genes, exhibits a presence or absence variation due to a 6.7-kb deletion in various populations. In this study, variation screening of the LILRA3 gene revealed high allele frequency of the 6.7-kb LILRA3 deletion (71%) in Japanese, in contrast to the frequency reported for the other populations. In addition, we identified a splice acceptor mutation in intron 1 with allele frequency of 19%, resulting in three alternatively spliced isoforms. Surprisingly, all of these isoforms were found to contain premature termination codons (PTCs) in the exon 3. Taken together, approximately 80% of Japanese lack functional LILRA3 alleles. The maximum likelihood coalescent analysis suggested that two major lineages, functional alleles and PTC-containing alleles, have been maintained for 2.75 million years in humans. These results prompted us to hypothesize that balancing selection had maintained both the functional and non-functional...Continue Reading

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Citations

Jun 27, 2012·Brain : a Journal of Neurology·Gurman KaurLars Fugger
Oct 7, 2008·Genome Research·Jeffrey M KiddEvan E Eichler
May 8, 2009·Genes and Immunity·D OrdóñezC Vilches
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Mar 1, 2011·Evolutionary Applications·Bernard J Crespi
Aug 10, 2016·Frontiers in Immunology·Laura Emily Hudson, Rachel Louise Allen
Dec 1, 2018·Proceedings of the National Academy of Sciences of the United States of America·Chikashi TeraoFumihiko Matsuda
Feb 3, 2021·Journal of Human Genetics·Kouyuki HirayasuRikinari Hanayama

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