Long-term persistence of ciprofloxacin-resistant Haemophilus influenzae in patients with cystic fibrosis

The Journal of Infectious Diseases
José CamposF Baquero

Abstract

Ciprofloxacin has been a major advance in the treatment of chronic respiratory infections. Three patients with cystic fibrosis and colonized by 5 nontypeable Haemophilus influenzae strains exhibiting low- (MIC, 2 microg/mL) and high-level ciprofloxacin resistance (MICs, 16-32 microg/mL) are described. The patients had received several courses of ciprofloxacin. These MICs represent a decrease in ciprofloxacin susceptibility of 200-3200 times. Molecular epidemiologic methods demonstrated that 2 patients were chronically colonized by their own ciprofloxacin-resistant strains for > or = 15-17 months. Three strains showed simultaneous resistance to ampicillin and chloramphenicol by enzyme inactivation, and 2 had ampicillin resistance without beta-lactamase activity. These data suggest that the emergence and long-term persistence of ciprofloxacin-resistant H. influenzae in patients with cystic fibrosis can be a consequence of antibiotic treatment.

Citations

Jul 27, 1999·International Journal of Antimicrobial Agents·A M SeftonJ D Williams
Jan 5, 2000·Microbes and Infection·M L Hutchison, J R Govan
Jul 28, 2004·Avian Pathology : Journal of the W.V.P.A·Young J LeeRyun B Tak
Jun 25, 1999·The Journal of Antimicrobial Chemotherapy·R M BannatyneM C Jackson
Feb 7, 2007·Antimicrobial Agents and Chemotherapy·María Pérez-VázquezJosé Campos
Jan 9, 2009·Journal of Clinical Microbiology·Shigeki NakamuraShigeru Kohno
Oct 26, 2012·Interdisciplinary Perspectives on Infectious Diseases·Axel Dalhoff
Jan 14, 2004·Emerging Infectious Diseases·Teresa BastidaCarles Alonso-Tarrés
Nov 12, 2014·Antimicrobial Agents and Chemotherapy·Carmen PuigJosefina Liñares
Mar 1, 2002·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Fernando BaqueroWilliam J. Novick
Jun 1, 1997·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Fernando BaqueroFernando Baquero-Artigao
Jul 9, 2014·Antimicrobial Agents and Chemotherapy·I H NorvilleT P Atkins
Nov 16, 2011·Expert Review of Respiratory Medicine·Yvonne J Huang, Susan V Lynch

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy & Infectious Diseases

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Allergy & Infectious Diseases (ASM)

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.